{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T05:51:23Z","timestamp":1775713883867,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Otolaryngology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Acinic cell carcinoma with high-grade transformation of the salivary gland is an unusual variant with less than fifty cases being reported in the literature. It is characterized by a low- and high-grade component juxtaposed with one another and tends to take on a more aggressive clinical course than its low-grade counterpart, suggesting a poor clinical outcome. We, hereby, report a case of acinic cell carcinoma in a 48-year-old woman with a 6-month history of a right parotid facial swelling rapidly increasing in size. The tumor was initially resected; however, residual focal tissue subsequently revealed areas typical of low-grade acinic cell carcinoma as well as high-grade transformation\/dedifferentiation via histopathology.<\/jats:p>","DOI":"10.1155\/2017\/7296467","type":"journal-article","created":{"date-parts":[[2017,5,14]],"date-time":"2017-05-14T17:00:58Z","timestamp":1494781258000},"page":"1-4","source":"Crossref","is-referenced-by-count":8,"title":["High-Grade Transformation (Dedifferentiation) of Acinic Cell Carcinoma of the Parotid Gland: Report of an Unusual Variant"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1116-2040","authenticated-orcid":true,"given":"Sarah S.","family":"Al-Otaibi","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head & Neck Surgery, King Faisal Specialist Hospital & Research Centre, MBC 47, P.O. 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