{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:47:47Z","timestamp":1766087267480,"version":"3.41.2"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T00:00:00Z","timestamp":1513814400000},"content-version":"vor","delay-in-days":354,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010166","name":"Xiamen Municipal Bureau of Science and Technology","doi-asserted-by":"publisher","award":["3502Z20154058"],"award-info":[{"award-number":["3502Z20154058"]}],"id":[{"id":"10.13039\/100010166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005270","name":"Fujian Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2017D022"],"award-info":[{"award-number":["2017D022"]}],"id":[{"id":"10.13039\/501100005270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005270","name":"Fujian Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2009Y01010666"],"award-info":[{"award-number":["2009Y01010666"]}],"id":[{"id":"10.13039\/501100005270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>The present study aimed to investigate the therapeutic effects of the Chinese herbal medicine Yin Zhi Huang soup (YZS) in an experimental autoimmune prostatitis (EAP) rat model. In total, 48 rats were randomly divided into the following four groups (<jats:italic>n<\/jats:italic> = 12\/group): saline group, pathological model group, Qianlietai group, and YZS group. We determined the average wet weight of the prostate tissue, the ratio of the wet weight of the prostate tissue to body weight, tumor necrosis factor\u2010alpha (TNF\u2010<jats:italic>\u03b1<\/jats:italic>) levels in the blood serum, the expression of inducible nitric oxide synthase (iNOS) in the rats\u2019 prostate tissues, and the pathological changes in the prostate tissue using light microscopy. YZS reduced the rats\u2019 prostate wet weight, the ratio of the prostate wet weight to body weight, and TNF\u2010<jats:italic>\u03b1<\/jats:italic> levels in the blood serum and inhibited the expression of iNOS in the rats\u2019 prostate tissues (<jats:italic>P<\/jats:italic> &lt; 0.05). Following YZS treatment, the pathological changes in the rats\u2019 prostates were improved compared with those in the model group (<jats:italic>P<\/jats:italic> &lt; 0.05). Furthermore, YZS treatment reduced inflammatory changes in the prostate tissue. It also significantly suppressed proinflammatory cytokines, such as TNF\u2010<jats:italic>\u03b1<\/jats:italic>, and chemokines, such as iNOS, in the rat model of EAP.<\/jats:p>","DOI":"10.1155\/2017\/7312938","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T23:33:17Z","timestamp":1513899197000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Anti\u2010Inflammatory Effects of a Yin Zhi Huang Soup in an Experimental Autoimmune Prostatitis Rat Model"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0744-8575","authenticated-orcid":false,"given":"Longsheng","family":"Deng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xikui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weikun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taikun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinchun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qizhong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changming","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanyu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,21]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2015.045"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.05.100"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.2268"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2010.4"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.2013.31.2.150"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2490-14-53"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.22595"},{"key":"e_1_2_10_8_2","first-page":"2440","article-title":"Effects of Buzhong Yiqi Decoction added with Centalla Asiatica on Inflammatory Factors in Rats with Chronic Non-bacterial Prostatitis. 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