{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:37:52Z","timestamp":1792449472016,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T00:00:00Z","timestamp":1500508800000},"content-version":"vor","delay-in-days":200,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sri Lankan Treasury","award":["TG 11\/60"],"award-info":[{"award-number":["TG 11\/60"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Ethanol (95%) and dichloromethane\u2009:\u2009methanol (1\u2009:\u20091) bark extracts of authenticated Ceylon cinnamon were investigated for range of antilipidemic activities (ALA): HMG\u2010CoA reductase, lipase, cholesterol esterase, and cholesterol micellization inhibitory activities and bile acids binding in vitro. Individual compounds in bark extracts were also evaluated. Bark extracts showed ALA in all the assays studied. The IC<jats:sub>50<\/jats:sub> (<jats:italic>\u03bc<\/jats:italic>g\/mL) values ranged within 153.07 \u00b1 8.38\u2013277.13 \u00b1 32.18, 297.57 \u00b1 11.78\u2013301.09 \u00b1 4.05, 30.61 \u00b1 0.79\u201334.05 \u00b1 0.41, and 231.96 \u00b1 9.22\u2013478.89 \u00b1 9.27, respectively, for HMG\u2010CoA reductase, lipase, cholesterol esterase, and cholesterol micellization inhibitory activities. The bile acids binding (3\u2009mg\/mL) for taurocholate, glycodeoxycholate, and chenodeoxycholate ranged within 19.74 \u00b1 0.31\u201320.22 \u00b1 0.31, 21.97 \u00b1 2.21\u201326.97 \u00b1 1.61, and 16.11 \u00b1 1.42\u201319.11 \u00b1 1.52%, respectively. The observed ALA were moderate compared to the reference drugs studied. Individual compounds in bark extracts ranged within 2.14 \u00b1 0.28\u2013101.91 \u00b1 3.61 and 0.42 \u00b1 0.03\u201349.12 \u00b1 1.89\u2009mg\/g of extract. Cinnamaldehyde and gallic acid were the highest and the lowest among the tested compounds. The ethanol extract had highest quantity of individual compounds and ALA investigated. Properties observed indicate usefulness of Ceylon cinnamon bark in managing hyperlipidemia and obesity worldwide. Further, this study provides scientific evidence for the traditional claim that Ceylon cinnamon has antilipidemic activities.<\/jats:p>","DOI":"10.1155\/2017\/7347219","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T21:03:31Z","timestamp":1500584611000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Bark Extracts of Ceylon Cinnamon Possess Antilipidemic Activities and Bind Bile Acids In Vitro"],"prefix":"10.1155","volume":"2017","author":[{"given":"Walimuni Prabhashini Kaushalya Mendis","family":"Abeysekera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8761-6614","authenticated-orcid":false,"given":"Sirimal Premakumara Galbada","family":"Arachchige","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanigasekera Daya","family":"Ratnasooriya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,20]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2007.05.002"},{"key":"e_1_2_8_2_2","first-page":"81","article-title":"Hypolipidemic activity of Luffa Aegiptiaca fruits in cholesterol fed hypercholesterolemic rabbits","volume":"2","author":"Thayyil A. 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