{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T09:59:17Z","timestamp":1781690357803,"version":"3.54.5"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"crossref","award":["TCVGH-1063604D"],"award-info":[{"award-number":["TCVGH-1063604D"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"crossref","award":["RVHCY105001"],"award-info":[{"award-number":["RVHCY105001"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Taichung Veterans General Hospital, Chiayi Branch","award":["TCVGH-1063604D"],"award-info":[{"award-number":["TCVGH-1063604D"]}]},{"name":"Taichung Veterans General Hospital, Chiayi Branch","award":["RVHCY105001"],"award-info":[{"award-number":["RVHCY105001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>The purpose of this study was to investigate whether plasma pyridoxal 5\u2032-phosphate (PLP) and homocysteine were dependent on or independent of each other in order to be associated with inflammatory markers in patients with chronic kidney disease (CKD) or those receiving hemodialysis treatment. This was a cross-sectional study. Sixty-eight stage 2\u20135 CKD patients and 68 hemodialysis patients had one time fasting blood drawn for measurements of plasma PLP, pyridoxal (PL), homocysteine, and several inflammatory markers. Early CKD stage (stages 2-3) patients showed significantly lower plasma PLP levels and homocysteine concentrations than patients in an advanced CKD stage (stages 4-5) and those undergoing hemodialysis. Plasma PLP significantly correlated with CRP levels (partial<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msub><mml:mrow><mml:mi>r<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi>s<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>= \u22120.21,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>) and plasma PL significantly correlated with IL-10 levels (partial<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:msub><mml:mrow><mml:mi>r<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi>s<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>= \u22120.24,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math>), while plasma PLP plus PL significantly correlated with both CRP levels (partial<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:msub><mml:mrow><mml:mi>r<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi>s<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>= \u22120.20,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>) and interleukin-1<jats:italic>\u03b2<\/jats:italic>(partial<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mrow><mml:msub><mml:mrow><mml:mi>r<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi>s<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>= 0.22,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>) levels after adjusting for plasma homocysteine and other potential confounders. Plasma homocysteine displayed no significant correlations with any inflammatory markers. Vitamin B-6 status, rather than homocysteine, appeared to be a significant factor in relation to inflammatory responses for CKD and hemodialysis patients.<\/jats:p>","DOI":"10.1155\/2017\/7367831","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T21:00:58Z","timestamp":1506459658000},"page":"1-8","source":"Crossref","is-referenced-by-count":7,"title":["Vitamin B-6, Independent of Homocysteine, Is a Significant Factor in Relation to Inflammatory Responses for Chronic Kidney Disease and Hemodialysis Patients"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1299-5055","authenticated-orcid":true,"given":"Cheng-Hsu","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan"},{"name":"Division of Basic Medical Sciences, Department of Medical Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan"},{"name":"Department of Life Science, Tunghai University, Taichung 40705, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"En-Ling","family":"Yeh","sequence":"additional","affiliation":[{"name":"Graduate Program in Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Chung","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Chiayi Branch, Taichung Veterans General Hospital, Chiayi 60090, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Chien","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan"},{"name":"Department of Nutrition, Chung Shan Medical University Hospital, Taichung 40201, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2234-4464","authenticated-orcid":true,"given":"Yi-Chia","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan"},{"name":"Department of Nutrition, Chung Shan Medical University Hospital, Taichung 40201, 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