{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:19:03Z","timestamp":1790828343056,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T00:00:00Z","timestamp":1499731200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biomarkers"],"published-print":{"date-parts":[[2017,7,11]]},"abstract":"<jats:p>Preeclampsia is a devastating pregnancy-associated disorder characterized by the onset of hypertension, proteinuria, and edema with limited plausible pathophysiology known. Cystatin-C, a novel marker for the detection of renal impairment, is increased in preeclampsia at an early stage. This study was aimed to evaluate the diagnostic efficiency of Cystatin-C as an early marker of renal function in preeclampsia comparing it to the traditional renal markers. A hospital based comparative cross-sectional study was performed on 104 women (52 diagnosed cases of preeclampsia and 52 healthy pregnant women). Concentrations of Cystatin-C, creatinine, urea, and uric acid were measured in both the study groups. Mean serum Cystatin-C and uric acid levels were elevated in preeclampsia cases compared to controls (1.15 \u00b1 0.37 versus 0.55 \u00b1 0.12; 5.40 \u00b1 1.44 versus 3.97 \u00b1 0.68, resp.). ROC curve depicted that Cystatin-C had the highest diagnostic efficiency (sensitivity, 88.24%; specificity, 98.04%) compared to creatinine and uric acid. Serum Cystatin-C consequently seemed to closely reflect the renal functional changes, which are believed to lead to increased blood pressure levels and urinary excretion of albumin and may thus function as a marker for the stage of the transition between normal adaptive renal changes at term and preeclampsia.<\/jats:p>","DOI":"10.1155\/2017\/7406959","type":"journal-article","created":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T21:10:29Z","timestamp":1499807429000},"page":"1-7","source":"Crossref","is-referenced-by-count":21,"title":["Cystatin-C as a Marker for Renal Impairment in Preeclampsia"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2866-7969","authenticated-orcid":true,"given":"Apeksha","family":"Niraula","sequence":"first","affiliation":[{"name":"Department of Biochemistry, B.P. 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