{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:30:03Z","timestamp":1777455003944,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009571","name":"Universidad Nacional de San Luis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009571","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>The presence of pigment has been demonstrated in different nervous structures such as those of retina,<jats:italic>substantia nigra<\/jats:italic>, and<jats:italic>locus coeruleus<\/jats:italic>. These pigments have also been described in the pineal gland of different mammal species. Histochemical and ultrastructural studies of the pineal gland of female viscacha (<jats:italic>Lagostomus maximus maximus<\/jats:italic>) were performed to analyze the presence of pigmented cells under natural conditions and to evaluate a probable relation between pigment content and glandular activity during pregnancy. The following techniques were applied: hematoxylin-eosin, phosphotungstic acid-hematoxylin, Masson-Fontana silver, DOPA histochemistry, Schmorl\u2019s reaction and toluidine blue. Estradiol and progesterone serum levels were determined by RIA. The ultrastructural features of the pineal pigment granules were also analyzed. Pigment granules were observed in a random distribution, but the pigmented cells were frequently found near blood vessels. The pineal pigment was histochemically identified as melanin. Differences in the amount of pigmented cells were found between pregnant and nonpregnant viscachas. The ultrastructural analysis revealed the presence of premelanosomes and melanosomes. Estradiol and progesterone levels vary during pregnancy. In conclusion, the changes in the amount of pigment content and hormone levels may indicate that the pineal gland of female viscacha is susceptible to endocrine variations during pregnancy.<\/jats:p>","DOI":"10.1155\/2017\/7492960","type":"journal-article","created":{"date-parts":[[2017,12,17]],"date-time":"2017-12-17T23:34:24Z","timestamp":1513553664000},"page":"1-8","source":"Crossref","is-referenced-by-count":7,"title":["Pigmented Cells in the Pineal Gland of Female Viscacha (<i>Lagostomus maximus maximus<\/i>): A Histochemical and Ultrastructural Study"],"prefix":"10.1155","volume":"2017","author":[{"given":"Fabricio Ivan","family":"Busolini","sequence":"first","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), 5700 San Luis, Argentina"},{"name":"Histolog\u00eda, Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis, Avenida Ejercito de los Andes 950, Bloque I, Piso No. 1, 5700 San Luis, 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