{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:42:00Z","timestamp":1784558520882,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korean government, MSIP","award":["NRF-2015M3A9E3052336"],"award-info":[{"award-number":["NRF-2015M3A9E3052336"]}]},{"name":"Bio & Medical Technology Development Program of the National Research Foundation","award":["NRF-2015M3A9E3052336"],"award-info":[{"award-number":["NRF-2015M3A9E3052336"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Illicium verum<\/jats:italic> is used in traditional medicine to treat inflammation. The study investigates the effects of IVE and its component, <jats:italic>trans<\/jats:italic>-anethole (AET), on airway inflammation in ovalbumin- (OVA-) induced asthmatic mice. Asthma was induced in BALB\/c mice by systemic sensitization to OVA, followed by intratracheal, intraperitoneal, and aerosol allergen challenges. IVE and AET were orally administered for four weeks. We investigated the effects of treatment on airway hyperresponsiveness, IgE production, pulmonary eosinophilic infiltration, immune cell phenotypes, Th2 cytokine production in bronchoalveolar lavage, Th1\/Th2 cytokine production in splenocytes, forkhead box protein 3 (Foxp3) expression, and lung histology. IVE and AET ameliorated OVA-driven airway hyperresponsiveness (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>), pulmonary eosinophilic infiltration (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>), mucus hypersecretion (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>), and IL-4, IL-5, IL-13, and CCR3 production (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>), as well as IgE levels (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>). IVE and AET increased Foxp3 expression in lungs (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). IVE and AET reduced IL-4 and increased IFN-<jats:italic>\u03b3<\/jats:italic> production in the supernatant of splenocyte cultures (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). Histological studies showed that IVE and AET inhibited eosinophilia and lymphocyte infiltration in lungs (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>). These results indicate that IVE and AET exert antiasthmatic effects through upregulation of Foxp3<jats:sup>+<\/jats:sup> regulatory T cells and inhibition of Th2 cytokines, suggesting that IVE may be a potential therapeutic agent for allergic lung inflammation.<\/jats:p>","DOI":"10.1155\/2017\/7506808","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T17:01:26Z","timestamp":1505408486000},"page":"1-12","source":"Crossref","is-referenced-by-count":25,"title":["<i>Illicium verum<\/i> Extract and <i>Trans<\/i>-Anethole Attenuate Ovalbumin-Induced Airway Inflammation via Enhancement of Foxp3<sup>+<\/sup> Regulatory T Cells and Inhibition of Th2 Cytokines in Mice"],"prefix":"10.1155","volume":"2017","author":[{"given":"Yoon-Young","family":"Sung","sequence":"first","affiliation":[{"name":"Mibyeong Research Center, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 305-811, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Hyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Traditional Medicine and Bioscience, Daejeon University, Daejeon 300-716, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1711-0906","authenticated-orcid":true,"given":"Dong-Seon","family":"Kim","sequence":"additional","affiliation":[{"name":"KM Convergence Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 305-811, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of Traditional Medicine and Bioscience, Daejeon University, Daejeon 300-716, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3588-3635","authenticated-orcid":true,"given":"Ho Kyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Mibyeong Research Center, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 305-811, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.03124.x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2013.06.028"},{"issue":"2","key":"3","first-page":"165","volume":"15","year":"2016","journal-title":"Journal of Drugs in 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