{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:50:42Z","timestamp":1792043442631,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical Scientific Research Foundation of Guangdong Province","award":["A2015395"],"award-info":[{"award-number":["A2015395"]}]},{"name":"Medical Scientific Research Foundation of Guangdong Province","award":["2014A020212617"],"award-info":[{"award-number":["2014A020212617"]}]},{"name":"Medical Scientific Research Foundation of Guangdong Province","award":["JCYJ20150331142757389"],"award-info":[{"award-number":["JCYJ20150331142757389"]}]},{"name":"Medical Scientific Research Foundation of Guangdong Province","award":["S2013040012296"],"award-info":[{"award-number":["S2013040012296"]}]},{"name":"Medical Scientific Research Foundation of Guangdong Province","award":["81301529"],"award-info":[{"award-number":["81301529"]}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"crossref","award":["A2015395"],"award-info":[{"award-number":["A2015395"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"crossref","award":["2014A020212617"],"award-info":[{"award-number":["2014A020212617"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"crossref","award":["JCYJ20150331142757389"],"award-info":[{"award-number":["JCYJ20150331142757389"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"crossref","award":["S2013040012296"],"award-info":[{"award-number":["S2013040012296"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"crossref","award":["81301529"],"award-info":[{"award-number":["81301529"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shenzhen Science and Technology Project","award":["A2015395"],"award-info":[{"award-number":["A2015395"]}]},{"name":"Shenzhen Science and Technology Project","award":["2014A020212617"],"award-info":[{"award-number":["2014A020212617"]}]},{"name":"Shenzhen Science and Technology Project","award":["JCYJ20150331142757389"],"award-info":[{"award-number":["JCYJ20150331142757389"]}]},{"name":"Shenzhen Science and Technology Project","award":["S2013040012296"],"award-info":[{"award-number":["S2013040012296"]}]},{"name":"Shenzhen Science and Technology Project","award":["81301529"],"award-info":[{"award-number":["81301529"]}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["A2015395"],"award-info":[{"award-number":["A2015395"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2014A020212617"],"award-info":[{"award-number":["2014A020212617"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["JCYJ20150331142757389"],"award-info":[{"award-number":["JCYJ20150331142757389"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["S2013040012296"],"award-info":[{"award-number":["S2013040012296"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["81301529"],"award-info":[{"award-number":["81301529"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["A2015395"],"award-info":[{"award-number":["A2015395"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2014A020212617"],"award-info":[{"award-number":["2014A020212617"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["JCYJ20150331142757389"],"award-info":[{"award-number":["JCYJ20150331142757389"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["S2013040012296"],"award-info":[{"award-number":["S2013040012296"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81301529"],"award-info":[{"award-number":["81301529"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>It has been controversial whether ankylosing spondylitis (AS) and nonradiographic axial spondyloarthritis (nr-axSpA) are separate or different phases of radiographic progression. We determined that serum calprotectin level (ng\/ml) was higher in AS (15.30\u2009\u00b1\u20096.49) and nr-axSpA (17.76\u2009\u00b1\u20098.59) patients than in healthy individuals (7.40\u2009\u00b1\u20092.67). No difference was observed in calprotectin level between these two groups. Elevated calprotectin was positively correlated with ESR, CRP, BASDAI, and ASDAS as well as SPARCC scoring and had no correlation with BASFI and mSASSS. No correlation was observed between calprotectin and Wnt\/<jats:italic>\u03b2<\/jats:italic>-catenin pathway markers. Serum calprotectin can be used as a marker for inflammation in both nr-axSpA and AS, while it does not contribute to the discrimination of AS and nr-axSpA. Calprotectin-mediated inflammation was not correlated with principle effectors of Wnt\/<jats:italic>\u03b2<\/jats:italic>-catenin pathway, indicating that inflammation and bone fusion might be separate processes of the disease.<\/jats:p>","DOI":"10.1155\/2017\/7574147","type":"journal-article","created":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T21:03:40Z","timestamp":1495659820000},"page":"1-5","source":"Crossref","is-referenced-by-count":22,"title":["Discriminating Value of Calprotectin in Disease Activity and Progression of Nonradiographic Axial Spondyloarthritis and Ankylosing Spondylitis"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5073-1205","authenticated-orcid":true,"given":"Jinxian","family":"Huang","sequence":"first","affiliation":[{"name":"Rheumatology Department, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Yin","sequence":"additional","affiliation":[{"name":"Rheumatology Department, The Fourth People\u2019s Hospital of Shenzhen, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxiang","family":"Song","sequence":"additional","affiliation":[{"name":"The Third People\u2019s Hospital of Shenzhen, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjin","family":"Cui","sequence":"additional","affiliation":[{"name":"Rheumatology Department, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Rheumatology Department, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Rheumatology Department, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.133645"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.108233"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-014-2663-6"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-1981-0"},{"issue":"2","key":"5","first-page":"146","volume":"39","year":"2014","journal-title":"Acta Reumatol\u00f3gica Portuguesa"},{"issue":"9","key":"6","first-page":"1527","volume":"60","year":"2014","journal-title":"Clinical Laboratory"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1002\/art.27231"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756-185X.2012.01734.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200216"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1186\/ar4096"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.102046"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/nm1638"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.077800"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2520"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-02-0446"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1097\/JIM.0000000000000095"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2011.648953"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205506"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1002\/art.21445"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.020503"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000071"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062605"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1002\/art.39420"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2017.1285700"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1223-2"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1008647"}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2017\/7574147.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2017\/7574147.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2017\/7574147.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T22:50:58Z","timestamp":1589755858000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/dm\/2017\/7574147\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":27,"alternative-id":["7574147","7574147"],"URL":"https:\/\/doi.org\/10.1155\/2017\/7574147","relation":{},"ISSN":["0278-0240","1875-8630"],"issn-type":[{"value":"0278-0240","type":"print"},{"value":"1875-8630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}