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These uses prompted us to evaluate estrogenic activity of <jats:italic>Lannea acida<\/jats:italic> bark ethanolic extract and its antiosteoporotic potential in ovariectomized Wistar rats. <jats:italic>In vitro<\/jats:italic>, the E\u2010screen assay was used to assess the ability of <jats:italic>L. acida<\/jats:italic> extract to induce MCF\u20107 cells proliferation. <jats:italic>In vivo<\/jats:italic>, a 3\u2010day uterotrophic assay and a 12\u2010week oral treatment in ovariectomized adult rats were carried out to evaluate the ability of <jats:italic>L. acida<\/jats:italic> extract to prevent bone mass loss. <jats:italic>L. acida<\/jats:italic> extract induced MCF\u20107 cell proliferation. <jats:italic>In vivo<\/jats:italic>, it significantly increased the uterine wet weight, uterine and vaginal epithelial heights, and mammary glands differentiation. At 200\u2009mg\/kg, a long\u2010term treatment with the extract prevented body weight gain (<jats:italic>p<\/jats:italic> &lt; 0.05) and loss of bone mass and\/or density (<jats:italic>p<\/jats:italic> &lt; 0.05) induced by ovariectomy. Also, a significant (<jats:italic>p<\/jats:italic> &lt; 0.001) decrease of alkaline phosphatase activity was observed with 50\u2009mg\/kg. <jats:italic>L. acida<\/jats:italic> extract improved bone microarchitecture and could restore normal bone mineralization by increasing the inorganic phosphorus and calcium level in bone. These findings provide evidence that <jats:italic>Lannea acida<\/jats:italic> is a potential alternative for the prevention of postmenopausal osteoporosis.<\/jats:p>","DOI":"10.1155\/2017\/7829059","type":"journal-article","created":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T23:33:31Z","timestamp":1511825611000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<i>Lannea acida<\/i> A. Rich. 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