{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T06:51:48Z","timestamp":1763967108727,"version":"3.37.3"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science Funding Committee of Shandong province","award":["ZR2015PH022","81270072"],"award-info":[{"award-number":["ZR2015PH022","81270072"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["ZR2015PH022","81270072"],"award-info":[{"award-number":["ZR2015PH022","81270072"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Asthma is characterized by airway remodeling. Follistatin-like protein 1 (FSTL1) is an extracellular glycoprotein. Recent studies suggest that FSTL1 may participate in the pathogenesis of asthma. <jats:italic>Objectives<\/jats:italic>. To analyze the association between FSTL1 and some parameters and inspect the role of FSTL1 in asthma. <jats:italic>Methods<\/jats:italic>. We examined FSTL1 levels in 32 asthmatics and 25 controls. All subjects enrolled had routine blood tests, spirometry, and impulse oscillometry performed. Additionally, 15 of the 32 asthmatics underwent fibre optic bronchoscopy. Spearman rank analysis was performed to detect the correlation between FSTL1 and other parameters. <jats:italic>Results<\/jats:italic>. Plasma FSTL1 levels were higher in asthmatics (130.762\u2009\u00b1\u200946.029\u2009ng\/mL) than in controls (95.408\u2009\u00b1\u200933.938\u2009ng\/mL) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.009<\/mml:mn><\/mml:math>). Plasma FSTL1 levels were associated with fibrosis levels around the airways (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi mathvariant=\"normal\">r<\/mml:mi><mml:mi mathvariant=\"normal\">s<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.529<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.043<\/mml:mn><\/mml:math>) and <jats:italic>\u03b1<\/jats:italic>-smooth muscle actin (<jats:italic>\u03b1<\/jats:italic>-SMA) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi mathvariant=\"normal\">r<\/mml:mi><mml:mi mathvariant=\"normal\">s<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.554<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.032<\/mml:mn><\/mml:math>). FSTL1 levels in bronchoalveolar lavage fluid were associated with collagen I (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi mathvariant=\"normal\">r<\/mml:mi><mml:mi mathvariant=\"normal\">s<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.536<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.040<\/mml:mn><\/mml:math>), <jats:italic>\u03b1<\/jats:italic>-SMA (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi mathvariant=\"normal\">r<\/mml:mi><mml:mi mathvariant=\"normal\">s<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.561<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.029<\/mml:mn><\/mml:math>), fibrosis levels (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mi mathvariant=\"normal\">r<\/mml:mi><mml:mi mathvariant=\"normal\">s<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.779<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>), and the thickness of the airway reticular basement membrane (RBM) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\"><mml:mi mathvariant=\"normal\">r<\/mml:mi><mml:mi mathvariant=\"normal\">s<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.660<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M13\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.007<\/mml:mn><\/mml:math>). <jats:italic>Conclusions<\/jats:italic>. FSTL1 levels in asthmatics were linked with increased smooth muscle mass and thickened RBM. FSTL1 may contribute to airway remodeling in asthmatics.<\/jats:p>","DOI":"10.1155\/2017\/7918472","type":"journal-article","created":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T17:02:22Z","timestamp":1501779742000},"page":"1-11","source":"Crossref","is-referenced-by-count":12,"title":["The Correlation between FSTL1 Expression and Airway Remodeling in Asthmatics"],"prefix":"10.1155","volume":"2017","author":[{"given":"Yahui","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan 250012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan 250012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinxiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan 250012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine-Bronchoscopy Room, Qilu Hospital of Shandong University, Jinan 250012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingai","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan 250012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine-Bronchoscopy Room, Qilu Hospital of Shandong University, Jinan 250012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiping","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan 250012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junfei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan 250012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan 250012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liuzhao","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan 250012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan 250012, 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