{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:52:12Z","timestamp":1790214732649,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . To assess the effect of vitamin D supplementation on neuropathy specific quality of life (NeuroQoL) in patients with painful diabetic neuropathy.\n                    <jats:italic>Methods<\/jats:italic>\n                    . This prospective, open label study was conducted between June 2012 and April 2013. Patients with symptomatic diabetic neuropathy were given a single dose of 600,000\u2009IU intramuscular vitamin D, and NeuroQol was assessed at baseline and at five follow-up visits every 4 weeks.\n                    <jats:italic>Results<\/jats:italic>\n                    . Of 143 participants, 41.3% were vitamin D deficient (vitamin D\u2009&lt;\u200920\u2009ng\/ml). Treatment with vitamin D resulted in a significant increase in 25(OH)D (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn>0.0001<\/mml:mn>\n                    <\/mml:math>\n                    ) and a significant improvement in the NeuroQoL subscale score for emotional distress (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn>0.04<\/mml:mn>\n                    <\/mml:math>\n                    ), with no significant change in the other NeuroQoL domains of painful symptoms and paresthesia, loss of temperature and touch sensation, unsteadiness, limitation in daily activities, and interpersonal problems. There was a significant reduction in patient perception about foot problems on QoL of \u201cquite a lot\u201d (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn>0.05<\/mml:mn>\n                    <\/mml:math>\n                    ) and \u201cvery much\u201d (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn>0.0001<\/mml:mn>\n                    <\/mml:math>\n                    ) with a significant reduction in the baseline response of having a \u201cpoor\u201d QoL from 5.2% to 0.7% (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn>0.0001<\/mml:mn>\n                    <\/mml:math>\n                    ) and an increase in the response of an \u201cexcellent QoL\u201d from 1.5% to 7.4% (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn>0.0001<\/mml:mn>\n                    <\/mml:math>\n                    ).\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . Vitamin D is effective in improving quality of life in patients with painful diabetic neuropathy.\n                  <\/jats:p>","DOI":"10.1155\/2017\/7928083","type":"journal-article","created":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T18:36:33Z","timestamp":1514486193000},"page":"1-7","source":"Crossref","is-referenced-by-count":39,"title":["Improvement in Neuropathy Specific Quality of Life in Patients with Diabetes after Vitamin D Supplementation"],"prefix":"10.1155","volume":"2017","author":[{"given":"Uazman","family":"Alam","sequence":"first","affiliation":[{"name":"Department of Eye and Vision Sciences, Institute of Ageing and Chronic Disease, University of Liverpool and Aintree University Hospital NHS Foundation Trust, Liverpool, UK"},{"name":"Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, University of Manchester, Manchester, 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