{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:32:11Z","timestamp":1759336331607,"version":"3.37.3"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Polish Ministry of Science and Higher Education","award":["DI2014 005044"],"award-info":[{"award-number":["DI2014 005044"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Receptors for advanced glycation end-products (RAGE) mediate the inflammatory reaction that follows aneurysmal subarachnoid haemorrhage. Soluble RAGE (sRAGE) may function as a decoy receptor. The significance of this endogenous anti-inflammatory mechanism in subarachnoid haemorrhage (SAH) remains unknown. The present study aims to analyse sRAGE levels in the cerebrospinal fluid (CSF) of SAH patients. sRAGE levels were assayed by ELISA kit in 47 CSF samples collected on post-SAH days 0\u20133, 5\u20137, and 10\u201314 from 27 SAH patients with acute hydrocephalus. CSF levels of sRAGE were compared with a control group and correlated with other monitored parameters. In the control group, the CSF contained only a trace amount of sRAGE. By contrast, the CSF of 20 SAH patients collected on post-SAH days 0\u20133 was found to contain statistically significant higher levels of sRAGE (mean concentration 3.91\u2009pg\/mL,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>). The most pronounced difference in CSF sRAGE levels between good and poor outcome patients was found on days 0\u20133 post-SAH but did not reach the significance threshold (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.234<\/mml:mn><\/mml:math>). CSF sRAGE levels did not change significantly during hospitalisation (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.868<\/mml:mn><\/mml:math>) and correlated poorly with treatment outcome, systemic inflammatory markers, and other monitored parameters. Our study revealed an early and constant increase of sRAGE level in the CSF of SAH patients.<\/jats:p>","DOI":"10.1155\/2017\/7931534","type":"journal-article","created":{"date-parts":[[2017,5,29]],"date-time":"2017-05-29T21:01:32Z","timestamp":1496091692000},"page":"1-7","source":"Crossref","is-referenced-by-count":6,"title":["Increase of Soluble RAGE in Cerebrospinal Fluid following Subarachnoid Haemorrhage"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4814-2000","authenticated-orcid":true,"given":"Bartosz","family":"Sok\u00f3\u0142","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"W\u0105sik","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Jankowski","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcin","family":"Ho\u0142ysz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Witold","family":"Ma\u0144ko","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Therapy, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Juszkat","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Poznan University of Medical Sciences, Poznan, Poland"},{"name":"Department of General and Interventional Radiology, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Ma\u0142kiewicz","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Therapy, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9046-6802","authenticated-orcid":true,"given":"Pawe\u0142 P.","family":"Jagodzi\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.298.6674.636"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1991.75.1.0008"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-016-0305-3"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3171\/2009.10.focus09223"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/394036"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-013-0257-2"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.533315"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1179\/174313209X393564"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-010-8155-z"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-013-0316-8"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000125886.48838.7E"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2013.147"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151853"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-009-9276-y"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.05.002"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-7-17"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1433.056"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300523"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1038\/srep21890"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1159\/000357002"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.711"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.3171\/2012.2.PEDS11491"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.5808\/GI.2013.11.4.224"},{"key":"24","doi-asserted-by":"crossref","first-page":"14998","DOI":"10.1016\/S0021-9258(18)42138-2","volume":"267","year":"1992","journal-title":"Journal of Biological Chemistry"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300523"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/403460"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m806948200"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2012.02646.x"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-15-24"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2013.11.023"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.631135"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2011.02.032"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.2174\/092986709787581888"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600456"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060290"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156171"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M038968"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-10-7"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13285"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(14)70084-5"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16629484"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2009.01.008"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/7931534.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/7931534.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/7931534.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T11:47:07Z","timestamp":1719229627000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2017\/7931534\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":42,"alternative-id":["7931534","7931534"],"URL":"https:\/\/doi.org\/10.1155\/2017\/7931534","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2017]]}}}