{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T03:51:44Z","timestamp":1772682704428,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002660","name":"Islamic Azad University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002660","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001828","name":"Erasmus Universiteit Rotterdam","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001828","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Although the causal relationship between<jats:italic>Helicobacter pylori<\/jats:italic>infection and the development of gastric cancer is firmly established, the exact nature of the pathogenicity factors of<jats:italic>H. pylori<\/jats:italic>that predispose to gastric oncogenesis remains incompletely characterized. We investigated the association between<jats:italic>H. pylori<\/jats:italic>virulence genotypes and disease in a well-characterized cohort consisting of 109<jats:italic>H. pylori<\/jats:italic>isolates from gastric biopsies originating from patients.<jats:italic>Methods<\/jats:italic>. The prevalence of genotype was assessed by PCR and related to clinical histopathological parameters.<jats:italic>Results<\/jats:italic>. The relation of<jats:italic>bab<\/jats:italic><jats:bold>A2<\/jats:bold>and<jats:italic>bab<\/jats:italic><jats:bold>B<\/jats:bold>negative and<jats:italic>ice<\/jats:italic><jats:bold>A1<\/jats:bold>positive genotype as a single genotype and the development of cases to GC was statistically significant (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>). The<jats:italic>cag<\/jats:italic><jats:bold>E<\/jats:bold>,<jats:italic>cag<\/jats:italic><jats:bold>A<\/jats:bold>, and<jats:italic>ice<\/jats:italic><jats:bold>A1<\/jats:bold>were found more commonly in patients with GC as compared with the other groups. The relation of the presence of<jats:italic>ice<\/jats:italic><jats:bold>A1<\/jats:bold>and the development of cases to GC was statistically significant (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.008<\/mml:mn><\/mml:math>), but<jats:italic>bab<\/jats:italic><jats:bold>A2<\/jats:bold>and<jats:italic>bab<\/jats:italic><jats:bold>B<\/jats:bold>alleles were not detected in these patients. These apparent negative associations were still statically significant (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0<\/mml:mn><\/mml:math>\u2009\u2009and 0.005).<jats:italic>Conclusion<\/jats:italic>. Our results show an elevated prevalence of infection with<jats:italic>H. pylori<\/jats:italic>strains carrying known virulence genotypes with high genetic diversity. This highlights the importance of identifying gene variants for an early detection of virulent genotypes.<\/jats:p>","DOI":"10.1155\/2017\/7942489","type":"journal-article","created":{"date-parts":[[2017,12,17]],"date-time":"2017-12-17T23:32:54Z","timestamp":1513553574000},"page":"1-6","source":"Crossref","is-referenced-by-count":18,"title":["<i>Helicobacter pylori<\/i>Pathogenicity Factors Related to Gastric Cancer"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9714-4358","authenticated-orcid":true,"given":"Kianoosh","family":"Dadashzadeh","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Sciences, Marand Branch, Islamic Azad University, Marand, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maikel P.","family":"Peppelenbosch","sequence":"additional","affiliation":[{"name":"Erasmus MC Cancer Institute, Erasmus University Rotterdam, Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akyala Ishaku","family":"Adamu","sequence":"additional","affiliation":[{"name":"Erasmus MC Cancer Institute, Erasmus University Rotterdam, Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-016-0506-0"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-12-199406150-00002"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2013.03.004"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-12-223"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.2217\/17460913.4.2.223"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2009.09.006"},{"issue":"10","key":"8","first-page":"2111","volume":"55","year":"1995","journal-title":"Cancer 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