{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T11:35:37Z","timestamp":1771068937205,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"DosentRx\u2122 Ltd."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic>Acute postoperative pain delays recovery and increases morbidity and mortality. Traditional administration of postoperative analgesics by nurses is often inefficient. The present study evaluated the safety, efficacy, and usability of a novel, patient-controlled analgesic dispenser, the PCoA Acute.<jats:italic>Methods.<\/jats:italic>A controlled pilot study was conducted at three medical centers. Patients scheduled for elective surgery were enrolled into two groups, both taking oral analgesics: a control group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">43<\/mml:mn><\/mml:math>), opioids dispensed by nurses, and a test group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">27<\/mml:mn><\/mml:math>), opioids dispensed via the PCoA Acute. Pill intake data were recorded. Pain ratings at rest and during movement were surveyed.<jats:italic>Results.<\/jats:italic>No severe adverse events were recorded. Average pill intake time was reduced from 8\u2009:\u200958 minutes in the control group to 1\u2009:\u200917 minutes in the test group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><\/mml:math>value &lt; 0.05). The test group took 67% more pills than the control group, indicating enhanced compliance. Pain scores were significantly lower for patients in the test group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><\/mml:math>value &lt; 0.05). Over 90% of PCoA Acute users were satisfied with its use.<jats:italic>Conclusions.<\/jats:italic>The study confirmed that PCoA Acute is safe and effective. It is well accepted by patients and medical staff. Its use can optimize pain medication administration.<\/jats:p>","DOI":"10.1155\/2017\/7962135","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T21:05:37Z","timestamp":1506632737000},"page":"1-12","source":"Crossref","is-referenced-by-count":6,"title":["Clinical Evaluation of a Novel Technology for Oral Patient-Controlled Analgesia, the<i>PCoA\u00ae Acute<\/i>Device, for Hospitalized Patients with Postoperative Pain, in Pilot Feasibility Study"],"prefix":"10.1155","volume":"2017","author":[{"given":"Stefan","family":"Wirz","sequence":"first","affiliation":[{"name":"Department of Anesthesia, Intensive Medicine, Pain Medicine\/Palliative Medicine, Center for Pain Medicine, CURA Hospital GFO, Bad Honnef, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Conrad","sequence":"additional","affiliation":[{"name":"DosentRx Ltd., 2 Hahar St., Har Tuv Industrial Zone A, 9980101 Har Tuv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7559-6388","authenticated-orcid":true,"given":"Ronit","family":"Shtrichman","sequence":"additional","affiliation":[{"name":"DosentRx Ltd., 2 Hahar St., Har Tuv Industrial Zone A, 9980101 Har Tuv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Schimo","sequence":"additional","affiliation":[{"name":"DosentRx Ltd., 2 Hahar St., Har Tuv Industrial Zone A, 9980101 Har Tuv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Interdisciplinary Intensive Care, Emergency Medicine and Pain Medicine, EvK-Protestant Hospital Herne, Herne, 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