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While the intricate balance between protein synthesis and breakdown regulates skeletal muscle mass, the suppression of basal protein synthesis may not account for the severe wasting induced by cancer. Therefore, recent research has shifted to the regulation of \u201canabolic resistance,\u201d which is the impaired ability of nutrition and exercise to stimulate protein synthesis. Emerging evidence suggests that oxidative metabolism can regulate both basal and induced muscle protein synthesis. While disrupted protein turnover and oxidative metabolism in cachectic muscle have been examined independently, evidence suggests a linkage between these processes for the regulation of cancer\u2010induced wasting. The primary objective of this review is to highlight the connection between dysfunctional oxidative metabolism and cancer\u2010induced anabolic resistance in skeletal muscle. First, we review oxidative metabolism regulation of muscle protein synthesis. Second, we describe cancer\u2010induced alterations in the response to an anabolic stimulus. Finally, we review a role for exercise to inhibit cancer\u2010induced anabolic suppression and mitochondrial dysfunction.<\/jats:p>","DOI":"10.1155\/2017\/8018197","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T23:31:33Z","timestamp":1513035093000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Linking Cancer Cachexia\u2010Induced Anabolic Resistance to Skeletal Muscle Oxidative Metabolism"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6469-9592","authenticated-orcid":false,"given":"Justin P.","family":"Hardee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan N.","family":"Montalvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3733-8796","authenticated-orcid":false,"given":"James A.","family":"Carson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,11]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2008.06.013"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00016.2008"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.060228"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-014-2418-6"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2014.894103"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30950"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2015.11.005"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1242\/bio.20136544"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980101)82:1<42::AID-CNCR5>3.0.CO;2-M"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024650"},{"key":"e_1_2_8_12_2","first-page":"2779","article-title":"Protein synthesis measured in vivo in muscle and liver of cachectic tumor-bearing mice","volume":"44","author":"Emery P. 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