{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T08:07:13Z","timestamp":1775376433852,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Previous studies have revealed that gene polymorphisms of inflammatory factors may influence the development or progression of periodontitis, a main cause of tooth loss in adults; however, due to limitations of individual studies, inconsistent findings were reported.<jats:italic>Objective<\/jats:italic>. To meta-analytically investigate the relationship between periodontitis and the Interleukin-4 (IL-4) and Interleukin-4 receptor (IL-4R) gene polymorphisms.<jats:italic>Methods<\/jats:italic>. Databases were searched for relevant case-control studies. After study selection based on the predefined selection criteria, methodological quality assessment and data extraction were conducted independently by two reviewers, before subsequent statistical analyses.<jats:italic>Results<\/jats:italic>. 37 studies involving 4,385 patients and 5,168 controls were included. All the studied IL-4 polymorphisms were not significantly associated with periodontitis, except the -33C\/T (CT versus CC: OR = 0.50, 95% CI = 0.28\u20130.88) associated with reduced AgP susceptibility. Positive association was found between IL-4R Q551 polymorphism and periodontitis susceptibility in three genetic models (R versus Q: OR = 1.59, 95% CI = 1.14\u20132.22; QR versus QQ: OR = 1.84, 95% CI = 1.21\u20132.80; RR + QR versus QQ: OR = 1.82, 95% CI = 1.22\u20132.72).<jats:italic>Conclusions<\/jats:italic>. A positive association exists between the IL-4R Q551R polymorphism and occurrence of CP. The IL-4 -33 CT genotype is negatively associated with the occurrence of AgP.<\/jats:p>","DOI":"10.1155\/2017\/8021279","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T17:09:47Z","timestamp":1489511387000},"page":"1-10","source":"Crossref","is-referenced-by-count":19,"title":["Association between IL-4 and IL-4R Polymorphisms and Periodontitis: A Meta-Analysis"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1975-5932","authenticated-orcid":true,"given":"Xiao-Wei","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Stomatology, Guangzhou Hospital of Integrated Traditional and West Medicine, Guangzhou 510800, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7030-5710","authenticated-orcid":true,"given":"Ya-Di","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Guangzhou Hospital of Integrated 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