{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:06:42Z","timestamp":1790327202942,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:00:00Z","timestamp":1511308800000},"content-version":"vor","delay-in-days":325,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2013SK5076"],"award-info":[{"award-number":["2013SK5076"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672262"],"award-info":[{"award-number":["81672262"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Mounting evidence has firmly established that increased exercise capacity (EC) is associated with considerable improvements in the survival of patients with cardiovascular disease (CVD) and that antistress capacity is a prognostic predictor of adverse cardiovascular events in patients with CVD. Previous studies have indicated that aerobic exercise (AE) and supplementation with <jats:italic>Rhodiola sacra<\/jats:italic> (RS), a natural plant pharmaceutical, improve EC and enable resistance to stress; however, the underlying mechanism remains unclear. This study explored the ability of AE and RS, alone or combined, to improve EC and ameliorate exhaustive exercise\u2010 (EE\u2010) induced stress and elucidate the mechanism involved. We found that AE and RS significantly increased EC in mice and ameliorated EE\u2010induced stress damage in skeletal and cardiac muscles (SCM); furthermore, a synergistic effect was detected for the first time. To our knowledge, the present work is the first to report that AE and RS activate mitophagy, mitochondrial dynamics, and biogenesis in SCM, both in the resting state and after EE. These data indicate that AE and RS synergistically improve EC in mice and protect SCM from EE\u2010induced stress by enhancing mitochondrial quality control, including the activation of mitophagy, mitochondrial dynamics, and biogenesis, both at rest and after EE.<\/jats:p>","DOI":"10.1155\/2017\/8024857","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T23:31:59Z","timestamp":1511393519000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Exercise Combined with <i>Rhodiola sacra<\/i> Supplementation Improves Exercise Capacity and Ameliorates Exhaustive Exercise\u2010Induced Muscle Damage through Enhancement of Mitochondrial Quality Control"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8642-9024","authenticated-orcid":false,"given":"Yaoshan","family":"Dun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4018-4006","authenticated-orcid":false,"given":"Suixin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6897-9583","authenticated-orcid":false,"given":"Wenliang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1838-6138","authenticated-orcid":false,"given":"Murong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6492-8989","authenticated-orcid":false,"given":"Ling","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,22]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61728-0"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2016.1178856"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.cj-13-0007"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2014.09.011"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000461"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003364"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.04.023"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.12740"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00106.2003"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00617.2006"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.115.003011"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.04.179"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13893"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2014.920956"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201200125"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171091"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.399345"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M702824200"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705070104"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00039.2014"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00337.2011"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5773"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-016-3402-2"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep30272"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.2174\/1573403x10666140404110229"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00677.2010"},{"key":"e_1_2_8_27_2","first-page":"293","article-title":"Rhodiola rosea: a possible plant adaptogen","volume":"6","author":"Kelly G. S.","year":"2001","journal-title":"Alternative Medicine Review"},{"key":"e_1_2_8_28_2","first-page":"57","article-title":"Effects of chronic Rhodiola rosea supplementation on sport performance and antioxidant capacity in trained male: preliminary results","volume":"50","author":"Parisi A.","year":"2010","journal-title":"Journal of Sports Medicine and Physical Fitness"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2007.0560"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-015-9622-8"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.4077\/CJP.2009.AMH029"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20780"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/904834"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.81.4.1843"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules19032793"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22200"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2016.268425"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.733410"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.05.004"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0b013e31825d9799"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.11.016"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00380.2014"},{"key":"e_1_2_8_43_2","first-page":"3","article-title":"Effects of alcohol aqueous extract from Rhodiola rosea L. roots on learning and memory","volume":"12","author":"Petkov V. D.","year":"1986","journal-title":"Acta Physiologica et Pharmacologica Bulgarica"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-016-2868-x"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/876825"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-016-1108-y"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1987149"},{"key":"e_1_2_8_48_2","first-page":"313","article-title":"The effect of exhaustive exercise on oxidative stress generation and antioxidant defense in guinea pigs","volume":"21","author":"Popovic L. M.","year":"2012","journal-title":"Advances in Clinical and Experimental Medicine"},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.300233"},{"key":"e_1_2_8_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14300"},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.2174\/138945011795529001"},{"key":"e_1_2_8_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5046"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.01.012"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.1023\/b:bebm.0000020211.24779.15"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2017\/8024857.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2017\/8024857.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2017\/8024857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T04:49:15Z","timestamp":1722919755000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2017\/8024857"}},"subtitle":[],"editor":[{"given":"Aditya","family":"Sen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1155\/2017\/8024857"],"URL":"https:\/\/doi.org\/10.1155\/2017\/8024857","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"2017-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8024857"}}