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Metalloproteinases (MMPs) have a vast biological effect on tumor progression, invasion, metastasis formation, and apoptosis. MMP expression was previously associated with survival in MPM. Our aim was to evaluate if genetic variability of <jats:italic>MMP<\/jats:italic> genes could also serve as a prognostic biomarker in MPM. <jats:italic>Methods.<\/jats:italic> We genotyped 199 MPM patients for ten polymorphisms: rs243865, rs243849 and rs7201, in <jats:italic>MMP2;<\/jats:italic> rs17576, rs17577, rs20544, and rs2250889 in <jats:italic>MMP9<\/jats:italic>; and rs1042703, rs1042704, and rs743257 in <jats:italic>MMP14<\/jats:italic>. We determined the influence on survival using Cox regression. <jats:italic>Results<\/jats:italic>. Carriers of polymorphic <jats:italic>MMP9<\/jats:italic> rs2250889 allele had shorter time to progression (TTP) (6.07 versus 10.03 months, HR\u2009=\u20092.45, 95% CI\u2009=\u20091.45\u20134.14, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>) and OS (9.23 versus 19.2 months, HR\u2009=\u20092.39, 95% CI\u2009=\u20091.37\u20134.18, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:math>). In contrast, carriers of at least one polymorphic <jats:italic>MMP9<\/jats:italic> rs20544 allele had longer TTP (10.93 versus 9.40 months, HR\u2009=\u20090.57, 95% CI\u2009=\u20090.38\u20130.86 <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.007<\/mml:mn><\/mml:math>) and OS (20.67 versus 13.50 months, HR\u2009=\u20090.56, 95% CI\u2009=\u20090.37\u20130.85, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.007<\/mml:mn><\/mml:math>). <jats:italic>MMP14<\/jats:italic> rs1042703 was associated with nominally shorter TTP (8.7 versus 9.27 months, HR\u2009=\u20092.09, 95% CI\u2009=\u20091.06\u20134.12, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.032<\/mml:mn><\/mml:math>). <jats:italic>Conclusions<\/jats:italic>. Selected <jats:italic>MMP<\/jats:italic> SNPs were associated with survival and could be used as potential genetic biomarkers in MPM.<\/jats:p>","DOI":"10.1155\/2017\/8069529","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T17:05:18Z","timestamp":1505235918000},"page":"1-8","source":"Crossref","is-referenced-by-count":11,"title":["Matrix Metalloproteinases Polymorphisms as Prognostic Biomarkers in Malignant Pleural Mesothelioma"],"prefix":"10.1155","volume":"2017","author":[{"given":"Danijela","family":"\u0160trbac","sequence":"first","affiliation":[{"name":"Institute of Oncology Ljubljana, Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5673-4458","authenticated-orcid":true,"given":"Katja","family":"Gori\u010dar","sequence":"additional","affiliation":[{"name":"Pharmacogenetics Laboratory, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, 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