{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T20:09:13Z","timestamp":1778098153397,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T00:00:00Z","timestamp":1489017600000},"content-version":"vor","delay-in-days":67,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Oncological Medicine"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Paraneoplastic cerebellar degeneration (PCD) is a rare anti\u2010Yo mediated paraneoplastic syndromes rarely that is infrequently associated with breast cancer. We present a case of a 52\u2010year\u2010old female presenting with diplopia, gait instability, dysarthria, dysphagia, nystagmus, and, most notably, new onset paroxysmal episodes of uncontrollable crying concerning for pseudobulbar affect (PBA). Serologic testing showed anti\u2010Yo antibodies. The patient was found to have stage IIIA breast cancer as the inciting cause of the paraneoplastic syndrome. The patient was treated with neoadjuvant chemotherapy, modified radical mastectomy, adjuvant Herceptin, and pertuzumab. She was given IVIG for paraneoplastic syndrome, antidepressants, and dextromethorphan\u2010quinidine (Nuedexta), the first FDA\u2010approved therapy for PBA. With multimodality therapy, she demonstrated significant improvement in neurologic and mood symptoms associated with PCD and PBA.<\/jats:p>","DOI":"10.1155\/2017\/8120689","type":"journal-article","created":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T16:04:55Z","timestamp":1489075495000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Anti\u2010Yo Mediated Paraneoplastic Cerebellar Degeneration Associated with Pseudobulbar Affect in a Patient with Breast Cancer"],"prefix":"10.1155","volume":"2017","author":[{"given":"Allison N.","family":"Martin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0622-725X","authenticated-orcid":false,"given":"Patrick M.","family":"Dillon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Brenin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Lapides","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,9]]},"reference":[{"key":"e_1_2_5_1_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-016-0058-x"},{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3270"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4741.2008.00604.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.2147\/tcrm.s53906"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.CON.0000455886.14298.a4"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852900026614"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.17.4.447"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200822070-00001"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12331"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3181f0c82b"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9776(03)00011-0"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.166028"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2014-206377"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-014-1745-9"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(08)60363-3"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.9.1708"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.4065\/81.11.1482"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21348"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.128"}],"container-title":["Case Reports in Oncological Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crionm\/2017\/8120689.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crionm\/2017\/8120689.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2017\/8120689","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T23:48:55Z","timestamp":1762472935000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2017\/8120689"}},"subtitle":[],"editor":[{"given":"Katsuhiro","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1155\/2017\/8120689"],"URL":"https:\/\/doi.org\/10.1155\/2017\/8120689","archive":["Portico"],"relation":{},"ISSN":["2090-6706","2090-6714"],"issn-type":[{"value":"2090-6706","type":"print"},{"value":"2090-6714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"2017-01-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8120689"}}