{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T11:50:56Z","timestamp":1768650656789,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471810"],"award-info":[{"award-number":["81471810"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2014A020211018"],"award-info":[{"award-number":["2014A020211018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2014A020212399"],"award-info":[{"award-number":["2014A020212399"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Plan Projects of Guangdong Province","award":["81471810"],"award-info":[{"award-number":["81471810"]}]},{"name":"Science and Technology Plan Projects of Guangdong Province","award":["2014A020211018"],"award-info":[{"award-number":["2014A020211018"]}]},{"name":"Science and Technology Plan Projects of Guangdong Province","award":["2014A020212399"],"award-info":[{"award-number":["2014A020212399"]}]},{"name":"Science and Technology Plan Projects of Guangdong Province","award":["81471810"],"award-info":[{"award-number":["81471810"]}]},{"name":"Science and Technology Plan Projects of Guangdong Province","award":["2014A020211018"],"award-info":[{"award-number":["2014A020211018"]}]},{"name":"Science and Technology Plan Projects of Guangdong Province","award":["2014A020212399"],"award-info":[{"award-number":["2014A020212399"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>The relationships between IVIM and DCE-MRI parameters in AS are not clear. We explore the correlation between intravoxel incoherent motion (IVIM) diffusion weighted imaging (DWI) and dynamic contrast-enhanced (DCE) parameters obtained on MR images in patients with ankylosing spondylitis (AS). Forty-four patients with AS were prospectively examined using a 1.5-T MR system. IVIM DWI was performed with 11 <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>b<\/mml:mi><\/mml:mrow><\/mml:math> values (range, 0\u2013800\u2009s\/mm<jats:sup>2<\/jats:sup>) for all patients. The correlation coefficients between IVIM and DCE-MRI parameters were analyzed using Spearman\u2019s method. Our results showed that intra- and interobserver reproducibility were excellent to relatively good (ICC\u2009=\u20090.804\u20130.981; narrow width of 95% limits of agreement). Moderate positive correlations were observed between pure molecular diffusion (Ds) and maximum enhancement (ME) and relative enhancement (RE) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>r<\/mml:mi><mml:mo>\u2009<\/mml:mo><mml:mo>=<\/mml:mo><mml:mo>\u2009<\/mml:mo><mml:mn fontstyle=\"italic\">0.700<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.607<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>\u2009<\/mml:mo><mml:mo>&lt;<\/mml:mo><mml:mo>\u2009<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>, resp.). Perfusion-related diffusion (Df) showed negative moderate correlation with ME (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>r<\/mml:mi><mml:mo>\u2009<\/mml:mo><mml:mo>=<\/mml:mo><mml:mo>\u2009<\/mml:mo><mml:mo>-<\/mml:mo><mml:mn fontstyle=\"italic\">0.608<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>\u2009<\/mml:mo><mml:mo>&lt;<\/mml:mo><mml:mo>\u2009<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>). However, no correlation was observed between perfusion fraction (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mrow><mml:mi>f<\/mml:mi><\/mml:mrow><\/mml:math>) and any parameters of ME, RE, TTP, and BE (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.093\u20130.213; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mi>P<\/mml:mi><mml:mo>\u2009<\/mml:mo><mml:mo>&gt;<\/mml:mo><mml:mo>\u2009<\/mml:mo><mml:mn fontstyle=\"italic\">0.165<\/mml:mn><\/mml:math>). In conclusion, the IVIM parameters, especially f, might play a critical role in detecting the progression of AS, because it can provide more perfusion information compared with DCE-MRI; besides the IVIM MRI is a noninvasive method.<\/jats:p>","DOI":"10.1155\/2017\/8135863","type":"journal-article","created":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T18:33:21Z","timestamp":1514399601000},"page":"1-9","source":"Crossref","is-referenced-by-count":8,"title":["Assessment of Correlation between Intravoxel Incoherent Motion Diffusion Weighted MR Imaging and Dynamic Contrast-Enhanced MR Imaging of Sacroiliitis with Ankylosing Spondylitis"],"prefix":"10.1155","volume":"2017","author":[{"given":"Yinghua","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Radiology, Third Affiliated Hospital of Southern Medical University and Academy of Orthopedics, 183 Zhongshan Da Dao Xi, Guangdong Province, Guangzhou 510630, 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihao","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, 1023-1063 Sha Tai Road, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2037-6446","authenticated-orcid":true,"given":"Zhiming","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Guangzhou Panyu Center Hospital, 8 Fuyu Dong Road, Panyu District, Guangzhou 511400, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4384-760X","authenticated-orcid":true,"given":"Shaolin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Third Affiliated Hospital of Southern Medical University and Academy of Orthopedics, 183 Zhongshan Da Dao Xi, 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