{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:50:56Z","timestamp":1767909056511,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Purpose.<\/jats:italic>To evaluate the short-term effectiveness of infliximab in controlling ocular manifestations in Beh\u00e7et\u2019s Disease (BD) patients candidate for pars plana vitrectomy, if given in a regimen before and after the planned procedure.<jats:italic>Patients and Methods.<\/jats:italic>30 eyes of 27 adult male BD patients with a mean age of 35.56\u2009yrs presented with refractory posterior uveitis not responding to immunosuppressive drugs and candidate for vitrectomy were included. Infliximab was given in a dose of 5\u2009mg\/kg intravenous infusion once every two weeks for 3 treatment sessions before the intended vitrectomy followed by 3 treatment sessions at two-week intervals, after vitrectomy.<jats:italic>Results.<\/jats:italic>Improvement of ocular manifestations was noted in all eyes, with complete resolution in 26 eyes (87%). Visual acuity improved from 0.23\u2009\u00b1\u20090.11 to 0.38\u2009\u00b1\u20090.17 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>\u2264<\/mml:mo><mml:mn>0.2<\/mml:mn><\/mml:math>), ESR decreased from 65.92\u2009mm\/hr\u2009\u00b1\u200917.32 SD to 24.93\u2009mm\/hr\u2009\u00b1\u20095.28 SD at the last treatment cycle (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>\u2264<\/mml:mo><mml:mn>0.1<\/mml:mn><\/mml:math>). The mean daily dose of systemic corticosteroids was tapered from 44.54\u2009mg\/d\u2009\u00b1\u20092.89 to 8.48\u2009mg\/d\u2009\u00b1\u20096.38 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>\u2264<\/mml:mo><mml:mn>0.2<\/mml:mn><\/mml:math>), and no relapses were noted during the follow-up period.<jats:italic>Conclusion.<\/jats:italic>Infliximab may be safe and effective in controlling posterior uveitis and inducing remissions if given in a regimen before and after vitrecomy in BD patients.<\/jats:p>","DOI":"10.1155\/2017\/8168369","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T22:12:54Z","timestamp":1491516774000},"page":"1-5","source":"Crossref","is-referenced-by-count":5,"title":["The Effectiveness of Pre- and Postoperative Infliximab in Controlling Beh\u00e7et\u2019s Disease Posterior Uveitis in Patients Undergoing Vitrectomy: A Preliminary Study"],"prefix":"10.1155","volume":"2017","author":[{"given":"Hossam El Din Mohamed","family":"Khalil","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Beni Sweif University, Beni Sweif, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2647-5883","authenticated-orcid":true,"given":"Heba A. 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