{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:08:19Z","timestamp":1740164899823,"version":"3.37.3"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Cardiology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>We describe a case of a young male without stroke risk factors who presented with a sudden onset of left-sided weakness, left hand numbness, and left eye blurriness. CT scan of the head without contrast and diffusion-weighted MRI of the brain with contrast revealed an ischemic stroke in the right middle cerebral artery distribution. Transesophageal echocardiography (TEE) revealed a mobile pedunculated mass on the posterior surface of the mitral valve. This mass was resected and pathology showed a cardiac papillary fibroelastoma (CPFE), which was determined to be the cause of the patient\u2019s cardioembolic stroke. Further workup also found that patient had microcytic anemia secondary to<jats:italic>\u03b2<\/jats:italic>-thalassemia intermedia, a rare hematologic disorder due to defective hemoglobin synthesis. Recently, another case report suggested<jats:italic>\u03b2<\/jats:italic>-thalassemia major may underlie the pathogenesis of CPFE.<jats:italic>\u03b2<\/jats:italic>-Thalassemia major causes a state of chronic inflammation and endothelial damage, which can mediate CPFE formation. Based on literature review, this is the first case report of a CPFE in a patient with<jats:italic>\u03b2<\/jats:italic>-thalassemia intermedia. This hypothesis-generating case report calls attention to the need for elucidating the relationship between CPFE and<jats:italic>\u03b2<\/jats:italic>-thalassemia in future studies to better understand the diagnosis and management of a rare cardiac tumor.<\/jats:p>","DOI":"10.1155\/2017\/8185601","type":"journal-article","created":{"date-parts":[[2017,3,26]],"date-time":"2017-03-26T17:01:09Z","timestamp":1490547669000},"page":"1-4","source":"Crossref","is-referenced-by-count":2,"title":["Papillary Fibroelastoma as a Cause of Cardiogenic Embolic Stroke in a<i>\u03b2<\/i>-Thalassemia Patient: Case Report and Literature Review"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2642-5712","authenticated-orcid":true,"given":"Re-I","family":"Chin","sequence":"first","affiliation":[{"name":"Saint Louis University School of Medicine, 1402 S Grand Blvd, Saint Louis, MO 63104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.","family":"Monda","sequence":"additional","affiliation":[{"name":"Saint Louis University School of Medicine, 1402 S Grand Blvd, Saint Louis, MO 63104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maulik","family":"Sheth","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, SSM St. Mary\u2019s Health Center, 6420 Clayton Rd, Richmond Heights, MO 63117, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Ogle","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, SSM St. Mary\u2019s Health Center, 6420 Clayton Rd, Richmond Heights, MO 63117, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Merenda","sequence":"additional","affiliation":[{"name":"Department of Pathology, SSM St. Mary\u2019s Health Center, 6420 Clayton Rd, Richmond Heights, MO 63117, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debapriya","family":"De","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, SSM St. Mary\u2019s Health Center, 6420 Clayton Rd, Richmond Heights, MO 63117, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9149(97)89149-7"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/s0003-4975(99)00700-6"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.03.569"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(05)70093-0"},{"issue":"1","key":"5","first-page":"35","volume":"32","year":"1956","journal-title":"The American Journal of Pathology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700650209"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-8703(03)00249-7"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.103.22.2687"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(97)00211-8"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.9.1171"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.04.006"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2002.130105"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-010-0754-0"},{"issue":"4","key":"15","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1055\/s-0038-1649879","volume":"74","year":"1995","journal-title":"Thrombosis and Haemostasis"},{"key":"16","first-page":"141","volume":"28, supplement 3","year":"1997","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2009.06.002"}],"container-title":["Case Reports in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cric\/2017\/8185601.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cric\/2017\/8185601.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cric\/2017\/8185601.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T01:54:11Z","timestamp":1568944451000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cric\/2017\/8185601\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":16,"alternative-id":["8185601","8185601"],"URL":"https:\/\/doi.org\/10.1155\/2017\/8185601","relation":{},"ISSN":["2090-6404","2090-6412"],"issn-type":[{"type":"print","value":"2090-6404"},{"type":"electronic","value":"2090-6412"}],"subject":[],"published":{"date-parts":[[2017]]}}}