{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T20:17:38Z","timestamp":1778098658926,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Special Fund for Key Laboratory of Xinjiang Uygur Autonomous Region","award":["2014KL014"],"award-info":[{"award-number":["2014KL014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Since the control rate of blood pressure is lower in mainland China, the aim of this study is to investigate the proportion of secondary causes and coexisting diseases of hypertension in hypertensive patients.<jats:italic>Methods<\/jats:italic>. Data on consecutive patients with hypertension who visited the Hypertension Center. Diseases were detected using an established strict screening protocol.<jats:italic>Results<\/jats:italic>. Detection rate of secondary causes and coexisting diseases of hypertension was 39.5% among 3003 hypertensive patients. Obstructive sleep apnea (OSA) was the most common, accounting for 24.7% of patients, followed by primary aldosteronism (PA) (5.8%) and PA + OSA (4.9%). Endocrine hypertension accounted for 12.1% of patients, including 10.7% of patients with PA, 1.1% with hypothyroidism, 0.1% with pheochromocytoma, 0.1% with Cushing\u2019s syndrome, and 0.1% with hyperthyroidism, respectively. Those who smoke, those who are obese, and those who have diabetes accounted for 31.3%, 27.5%, and 16.6% of total patients, respectively. There were overlapping conditions in secondary causes and coexisting diseases of hypertension. OSA was the most common in each age- and BMI-stratified group.<jats:italic>Conclusion<\/jats:italic>. Findings from the current study suggest an increasing frequency of secondary forms of hypertension, highlighting the burden of OSA and PA in hypertensive patients.<\/jats:p>","DOI":"10.1155\/2017\/8295010","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T21:02:44Z","timestamp":1497387764000},"page":"1-8","source":"Crossref","is-referenced-by-count":12,"title":["Detection of Secondary Causes and Coexisting Diseases in Hypertensive Patients: OSA and PA Are the Common Causes Associated with Hypertension"],"prefix":"10.1155","volume":"2017","author":[{"given":"Lei","family":"Wang","sequence":"first","affiliation":[{"name":"Hypertension Institute of Xinjiang, Hypertension Center of the People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3984-6084","authenticated-orcid":true,"given":"Nanfang","family":"Li","sequence":"additional","affiliation":[{"name":"Hypertension Institute of Xinjiang, Hypertension Center of the People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoguang","family":"Yao","sequence":"additional","affiliation":[{"name":"Hypertension Institute of Xinjiang, Hypertension Center of the People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guijuan","family":"Chang","sequence":"additional","affiliation":[{"name":"Hypertension Institute of Xinjiang, Hypertension Center of the People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hypertension Institute of Xinjiang, Hypertension Center of the People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mulalibieke","family":"Heizhati","sequence":"additional","affiliation":[{"name":"Hypertension Institute of Xinjiang, Hypertension Center of the People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menghui","family":"Wang","sequence":"additional","affiliation":[{"name":"Hypertension Institute of Xinjiang, Hypertension Center of the People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Luo","sequence":"additional","affiliation":[{"name":"Hypertension Institute of Xinjiang, Hypertension Center of the People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianqiong","family":"Kong","sequence":"additional","affiliation":[{"name":"Hypertension Institute of Xinjiang, Hypertension Center of the People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0140-6736(04)17018-9","volume":"364","year":"2004","journal-title":"Lancet"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.52.9582"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.03.045"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2013.32"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.111.179788"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000107251.49515.c2"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200305000-00001"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht534"},{"key":"9","first-page":"547","volume":"3","year":"2006","journal-title":"circulation"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0104"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054051"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1498"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0125"},{"key":"14","doi-asserted-by":"crossref","first-page":"263","DOI":"10.5664\/jcsm.27497","volume":"5","year":"2009","journal-title":"Journal of Clinical Sleep Medicine"},{"key":"15","first-page":"623","volume":"51","year":"2006","journal-title":"The Canadian Journal of Psychiatry"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.2223\/JPED.839"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1159\/000194971"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1981.tb11628.x"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199405000-00015"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.27.193"},{"issue":"6","key":"21","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1161\/HYPERTENSIONAHA.108.189141","volume":"51","year":"2008","journal-title":"Hypertension"},{"key":"22","first-page":"939","volume":"38","year":"2010","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"issue":"9","key":"23","first-page":"865","volume":"35","year":"2007","journal-title":"Zhonghua xin xue guan bing za zhi [Chinese journal of cardiovascular diseases]"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2015.02.001"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328350e53b"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200018060-00004"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.7.602"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.12.017"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-1170"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200112000-00022"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005113421901"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.4366"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.3418"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0537"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.108.189141"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-1442"},{"key":"38","doi-asserted-by":"crossref","first-page":"363","DOI":"10.5664\/jcsm.27878","volume":"6","year":"2010","journal-title":"Journal of Clinical Sleep Medicine"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S77710"},{"key":"40","first-page":"142","volume":"36","year":"2014","journal-title":"Journal of Psychiatric Research"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/953094"},{"key":"43","first-page":"125","volume":"29","year":"2008","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/8295010.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/8295010.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/8295010.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T04:08:55Z","timestamp":1602302935000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2017\/8295010\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":41,"alternative-id":["8295010","8295010"],"URL":"https:\/\/doi.org\/10.1155\/2017\/8295010","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}