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The effectiveness of ACI has been shown <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>, but the use of other cell types, including bone marrow and adipose-derived mesenchymal stem cells, is necessary because of the poor proliferation rate of isolated articular chondrocytes. In this investigation, we assessed the chondrogenic ability of human dental pulp stem cells (hDPSCs) to regenerate cartilage <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. hDPSCs and primary isolated rabbit chondrocytes were cultured in chondrogenic culture medium and found to express collagen II and aggrecan. Both cell types were cultured in 3% alginate hydrogels and implanted in a rabbit model of cartilage damage. Three months after surgery, significant cartilage regeneration was observed, particularly in the animals implanted with hDPSCs. Although the results presented here are preliminary, they suggest that hDPSCs may be useful for regeneration of articular cartilage.<\/jats:p>","DOI":"10.1155\/2017\/8309256","type":"journal-article","created":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T17:04:35Z","timestamp":1502903075000},"page":"1-9","source":"Crossref","is-referenced-by-count":75,"title":["<i>In Vivo<\/i> Articular Cartilage Regeneration Using Human Dental Pulp Stem Cells Cultured in an Alginate Scaffold: A Preliminary Study"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1506-7983","authenticated-orcid":true,"given":"Manuel","family":"Mata","sequence":"first","affiliation":[{"name":"Department of Pathology, Faculty of Medicine and Odontology, University of Valencia, Blasco Ib\u00e1\u00f1ez Avenue 15, 46010 Valencia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias (CIBERES), Monforte de Lemos Avenue, 3-5, Pabell\u00f3n 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