{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T07:52:00Z","timestamp":1766908320819,"version":"3.37.3"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004916","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Amazonas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004916","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>.<jats:italic> Byrsonima <\/jats:italic>is a promising neotropical genus, rich in flavonoids and triterpenes, with several proven pharmacological properties. Nevertheless,<jats:italic> Byrsonima duckeana <\/jats:italic>W. R. Anderson is an Amazonian species almost not studied.<jats:italic> Objective<\/jats:italic>. To assess the antioxidant, anti-inflammatory, and analgesic activities of<jats:italic> Byrsonima duckeana <\/jats:italic>leaves.<jats:italic> Materials and Methods<\/jats:italic>. We analyzed an ethanol extract and its fractions for polyphenol content and UHPLC-MS\/MS, phosphomolybdenum, DPPH, TBARS antioxidant tests, formalin-induced pain, carrageenan-induced peritonitis, acetic acid-induced abdominal writhings, and hot plate assays.<jats:italic> Results<\/jats:italic>. All the samples showed high polyphenol content and antioxidant capacity in the phosphomolybdenum, DPPH, and TBARS tests. We identified ethyl gallate, quinic acid, gallic acid, catechin, epicatechin, quercetrin, and quercetin in the samples.<jats:italic> B. duckeana<\/jats:italic> was able to reduce leukocyte migration in the carrageenan-induced peritonitis by 43% and the licking time in the formalin test by 57%. In the acetic acid-induced writhing test, the chloroform (FCL) and ethyl acetate (FEA) fractions were the most active samples. FEA was selected for the hot plate test, where all the dosages tested (5, 50, and 200\u2009mg\u00b7kg<jats:sup>\u22121<\/jats:sup>) showed significant analgesic activity.<jats:italic> Conclusion<\/jats:italic>.<jats:italic> B. duckeana <\/jats:italic>has interesting analgesic and antioxidant activities, due to its high phenolic content, especially phenolic acids.<\/jats:p>","DOI":"10.1155\/2017\/8367042","type":"journal-article","created":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T16:01:35Z","timestamp":1488816095000},"page":"1-8","source":"Crossref","is-referenced-by-count":8,"title":["Analgesic, Anti-Inflammatory, and Antioxidant Activities of<i> Byrsonima duckeana<\/i> W. R. Anderson (Malpighiaceae)"],"prefix":"10.1155","volume":"2017","author":[{"given":"Maria Christina dos Santos","family":"Verdam","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Federal University of Paran\u00e1, Curitiba, PR, Brazil"},{"name":"Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9528-746X","authenticated-orcid":true,"given":"Fernanda","family":"Guilhon-Simplicio","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Federal University of Amazonas, Manaus, AM, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kleyton Cardoso de","family":"Andrade","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Federal University of Amazonas, Manaus, AM, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina Lorena 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