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Currently, no specific treatment has been suggested for DCM treatment. This study demonstrated that myricetin (M) attenuated DCM\u2010associated cardiac injury in mice subjected to streptozotocin (SZT) and in neonatal rat cardiomyocytes (NRCM) challenged with high glucose. <jats:italic>In vivo<\/jats:italic> investigation demonstrated 6 months of M treatment (200\u2009mg\/kg\/d) significantly alleviated cardiac hypertrophy, apoptosis, and interstitial fibrosis. Mechanically, M treatment significantly increased the activity of Nrf2\/HO\u20101 pathway, strengthening antioxidative stress capacity evidenced by reversed activities of GPx and SOD, and decreased MDA production. M treatment also inhibited I<jats:italic>\u03ba<\/jats:italic>B<jats:italic>\u03b1<\/jats:italic>\/NF\u2010<jats:italic>\u03ba<\/jats:italic>B pathway, resulting in reduced secretion of inflammation cytokines including IL\u20101<jats:italic>\u03b2<\/jats:italic>, TNF\u2010<jats:italic>\u03b1<\/jats:italic>, and IL\u20106. Besides, the TGF<jats:italic>\u03b2<\/jats:italic>\/Smad3 signaling was also blunted in DCM mice treated with M. These beneficial effects of M treatment protected cardiomyocytes from apoptosis as shown by decreased TUNEL\u2010positive nucleus, c\u2010caspase 3, and Bax. Similar effects of M treatment could be reproduced in NRCM treated with high glucose. Furthermore, through silencing Nrf2 in NRCM, we found that the regulation of I<jats:italic>\u03ba<\/jats:italic>B<jats:italic>\u03b1<\/jats:italic>\/NF<jats:italic>\u03ba<\/jats:italic>B by M was independent on its function on Nrf2. Thus, we concluded that M possesses potential protective effects on DCM through inhibiting I<jats:italic>\u03ba<\/jats:italic>B<jats:italic>\u03b1<\/jats:italic>\/NF<jats:italic>\u03ba<\/jats:italic>B and enhancing Nrf2\/HO\u20101.<\/jats:p>","DOI":"10.1155\/2017\/8370593","type":"journal-article","created":{"date-parts":[[2017,9,24]],"date-time":"2017-09-24T21:01:09Z","timestamp":1506286869000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Myricetin Possesses Potential Protective Effects on Diabetic Cardiomyopathy through Inhibiting I<i>\u03ba<\/i>B<i>\u03b1<\/i>\/NF<i>\u03ba<\/i>B and Enhancing 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