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Previous microarray study reported that miR-214 was downregulated in the sigmoid colon of patients with active UC, but the roles of miR-214 in the pathogenesis of UC remain to be elucidated. In this study, significant lower level of miR-214-3p and higher level of STAT6 in the intestinal mucosa of active UC patients compared with the health controls were confirmed by quantitative real-time PCR. Results of luciferase reporter assays and western blot demonstrated that miR-214-3p directly targets STAT6 and negatively regulates the expression of STAT6 at the posttranscriptional level. Furthermore, the expression of miR-214-3p was decreased in TNF-<jats:italic>\u03b1<\/jats:italic>treated HT29 cells and STAT6 protein level was increased in a time-dependent manner. Silenced STAT6 and upregulation of miR-214-3p could decrease the level of INF-<jats:italic>\u03b3<\/jats:italic>in TNF-<jats:italic>\u03b1<\/jats:italic>treated HT29 cells. Additionally, the results of the present study indicate that miR-214-3p and STAT6 axis may be a novel therapeutic target for intestinal inflammation of patients with active UC.<\/jats:p>","DOI":"10.1155\/2017\/8524972","type":"journal-article","created":{"date-parts":[[2017,7,2]],"date-time":"2017-07-02T17:02:15Z","timestamp":1499014935000},"page":"1-7","source":"Crossref","is-referenced-by-count":12,"title":["Downregulation of miR-214-3p May Contribute to Pathogenesis of Ulcerative Colitis via Targeting STAT6"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0148-6826","authenticated-orcid":true,"given":"Jin-an","family":"Li","sequence":"first","affiliation":[{"name":"Department of Anus & Intestine Surgery, Three Gorges Central Hospital, Chongqing 404000, 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