{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:41:03Z","timestamp":1760132463532,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Beijing Natural Science Foundation of China","award":["7132187"],"award-info":[{"award-number":["7132187"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Respiratory Journal"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background and Objective<\/jats:italic>. TWIK-related acid-sensitive potassium channel 1 (TASK-1) is closely related to respiratory central control and neuronal injury. We investigated the effect of MV on TASK-1\u2019s functions and explored the mechanism using a rat model.<jats:italic>Methods<\/jats:italic>. Male Sprague-Dawley rats were randomized to three groups:<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mn fontstyle=\"italic\">1<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>high tidal volume (HVt): MV for four hours with Vt at 10\u2009mL\/kg;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mn fontstyle=\"italic\">2<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>low Vt (LVt): MV for four hours with Vt at 5\u2009mL\/kg;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mn fontstyle=\"italic\">3<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>basal (BAS): anesthetized and unventilated animals. We measured lung histology and plasma and brain levels of proteins (IL-6, TNF-<jats:italic>\u03b1<\/jats:italic>, and S-100B) and determined TASK-1 levels in rat brainstems as a marker of respiratory centre activity.<jats:italic>Results<\/jats:italic>. The LISs (lung injury scores) were significantly higher in the HVt group. Brain inflammatory cytokines levels were different to those in serum. TASK-1 levels were significantly lower in the MV groups (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.002<\/mml:mn><\/mml:math>) and the HVt group tended to have a lower level of TASK-1 than the LVt group.<jats:italic>Conclusion<\/jats:italic>. MV causes not only lung injury, but also brain injury. MV affects the regulation of the respiratory centre, perhaps causing damage to it. Inflammation is probably not the main mechanism of ventilator-related brain injury.<\/jats:p>","DOI":"10.1155\/2017\/8530352","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T17:08:15Z","timestamp":1506618495000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["The Effect of Mechanical Ventilation on TASK-1 Expression in the Brain in a Rat Model"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0875-8169","authenticated-orcid":true,"given":"Buqi","family":"Na","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Beijing Jishuitan Hospital, Beijing 100035, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1599-3741","authenticated-orcid":true,"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Peking University First 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