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ZF or lean rats received diet supplemented or not with Provinols for 8 weeks. Vasoconstriction in response to phenylephrine (Phe) was then assessed in small mesenteric arteries (SMA) and the aorta with emphasis on the contribution of cyclooxygenases (COX). Although no difference in vasoconstriction was observed between ZF and lean rats both in SMA and the aorta, Provinols affected the contribution of COX\u2010derived vasoconstrictor agents. The nonselective COX inhibitor, indomethacin, reduced vasoconstriction in vessels from both groups; however, lower efficacy was observed in Provinols\u2010treated rats. This was associated with a reduction in thromboxane\u2010A2 and 8\u2010isoprostane release. The selective COX\u20102 inhibitor, NS398, reduced to the same extent vasoconstriction in aortas from ZF and Provinols\u2010treated ZF rats. However, NS398 reduced response to Phe only in SMA from ZF rats. This was associated with a reduction in 8\u2010isoprostane and prostaglandin\u2010E release. Paradoxically, Provinols decreased COX\u20102 expression in the aorta, while it increased its expression in SMA. We provide here evidence of a subtle and paradoxical regulation of COX pathway by Provinols vessels from obese rats to maintain vascular tone within a physiological range.<\/jats:p>","DOI":"10.1155\/2017\/8536910","type":"journal-article","created":{"date-parts":[[2017,6,4]],"date-time":"2017-06-04T21:02:58Z","timestamp":1496610178000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Paradoxical Effect of Nonalcoholic Red Wine Polyphenol Extract, Provinols\u2122, in the Regulation of Cyclooxygenases in Vessels from Zucker Fatty Rats (<i>fa<\/i>\/<i>fa<\/i>)"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8363-1582","authenticated-orcid":false,"given":"Abdelali","family":"Agouni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadj 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