{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:03:14Z","timestamp":1740164594660,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>B-cell prolymphocytic leukemia (B-PLL) is a rare lymphoid neoplasm with an aggressive clinical course. Treatment strategies for B-PLL remain to be established, and, until recently, alemtuzumab was the only effective therapeutic option in patients harboring 17p deletions. Herein, we describe, for the first time, a case of B-cell prolymphocytic leukemia harboring a 17p deletion in a 48-year-old man that was successfully treated sequentially with idelalisib-rituximab\/ibrutinib followed by allogeneic hematopoietic stem cell transplant (allo-HSCT). After 5 months of therapy with idelalisib-rituximab, clinical remission was achieved, but the development of severe diarrhea led to its discontinuation. Subsequently, the patient was treated for 2 months with ibrutinib and the quality of the response was maintained with no severe adverse effects reported. A reduced-intensity conditioning allo-HSCT from a HLA-matched unrelated donor was performed, and, thereafter, the patient has been in complete remission for 10 months now. In conclusion, given the poor prognosis of B-PLL and the lack of effective treatment modalities, the findings here suggest that both ibrutinib and idelalisib should be considered as upfront therapy of B-PLL and as a bridge to allo-HSCT.<\/jats:p>","DOI":"10.1155\/2017\/8563218","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T17:04:18Z","timestamp":1501175058000},"page":"1-4","source":"Crossref","is-referenced-by-count":5,"title":["Sequential Kinase Inhibition (Idelalisib\/Ibrutinib) Induces Clinical Remission in B-Cell Prolymphocytic Leukemia Harboring a 17p Deletion"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0909-9601","authenticated-orcid":true,"given":"H.","family":"Coelho","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Hematologia, Centro Hospitalar de Vila Nova de Gaia\/Espinho, Vila Nova Gaia, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Badior","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Hematologia, Centro Hospitalar de Vila Nova de Gaia\/Espinho, Vila Nova Gaia, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Melo","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Hematologia, Centro Hospitalar de Vila Nova de Gaia\/Espinho, Vila Nova Gaia, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-007-9097-2"},{"year":"2008","key":"2"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-01-380139"},{"issue":"12","key":"4","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.4065\/80.12.1660","volume":"80","year":"2005","journal-title":"Mayo Clinic Proceedings"},{"issue":"8","key":"5","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1093\/jnci\/85.8.658","volume":"85","year":"1993","journal-title":"Natl Cancer Inst"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-008-0541-5"},{"key":"7","first-page":"426","volume":"5","year":"87","journal-title":"European Journal of Haematology"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1080\/10428190400004521"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404238"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13042"},{"issue":"5","key":"11","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1080\/10428190290021597","volume":"43","year":"2002","journal-title":"Leuk Lymphoma"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20843"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.119123"},{"issue":"9","key":"14","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1158\/1078-0432.CCR-16-1948","volume":"23","year":"2017","journal-title":"Clinical Cancer Research"},{"issue":"3","key":"15","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/bjh.14066","volume":"177","year":"2017","journal-title":"Br J Haematol"},{"journal-title":"British Journal of Haematology","year":"2016","key":"16"},{"issue":"9","key":"17","first-page":"586","volume":"13","year":"2015","journal-title":"Clinical Advances in Hematology & Oncology"},{"issue":"5","key":"18","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1586\/eci.09.31","volume":"5","year":"2009","journal-title":"Expert Review of Clinical Immunology"},{"issue":"10","key":"19","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.3109\/10428194.2015.1022770","volume":"56","year":"2015","journal-title":"Leuk Lymphoma"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2015.1084286"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-03-630772"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2017\/8563218.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2017\/8563218.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2017\/8563218.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T17:04:20Z","timestamp":1501175060000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crihem\/2017\/8563218\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":21,"alternative-id":["8563218","8563218"],"URL":"https:\/\/doi.org\/10.1155\/2017\/8563218","relation":{},"ISSN":["2090-6560","2090-6579"],"issn-type":[{"type":"print","value":"2090-6560"},{"type":"electronic","value":"2090-6579"}],"subject":[],"published":{"date-parts":[[2017]]}}}