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A total of 259 women receiving the in vitro fertilization-embryo transfer (IVF) cycle were enrolled in this study, including 52 women with positive ANA and anti-dsDNA (ANA+\/anti-dsDNA+ group), 86 women with positive ANA and negative anti-dsDNA (ANA+\/anti-dsDNA\u2212 group), and 121 women with negative ANA and anti-dsDNA (ANA\u2212\/anti-dsDNA\u2212 group). 136 nonpregnant women among 259 patients in the IVF-ET cycle were enrolled in the hormone replacement therapy frozen-thawed embryo transfer (HRT-TET) cycle. We compared basic characters and IVF outcomes among three groups in fresh embryo transfer and frozen-thawed embryo transfer cycle, respectively. The number of retrieved oocytes, available embryos, and high-quality embryos in the ANA+\/anti-dsDNA+ group was lower than those in the other two groups in the fresh embryo transfer cycle. The rates of fertilization, implantation, and clinical pregnancy in the ANA+\/anti-dsDNA+ group were the lowest, while the early miscarriage rate was the highest in the ANA+\/anti-dsDNA+ group both in the fresh embryo transfer cycle and in the frozen-thawed embryo transfer cycle. Our data suggested that anti-dsDNA antibody may be the essential marker for defective oocytes or embryos in infertile women with any type of ANA.<\/jats:p>","DOI":"10.1155\/2017\/8596181","type":"journal-article","created":{"date-parts":[[2017,4,30]],"date-time":"2017-04-30T21:01:53Z","timestamp":1493586113000},"page":"1-6","source":"Crossref","is-referenced-by-count":22,"title":["Impacts of Anti-dsDNA Antibody on In Vitro Fertilization-Embryo Transfer and Frozen-Thawed Embryo Transfer"],"prefix":"10.1155","volume":"2017","author":[{"given":"Jiao","family":"Fan","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center for The First Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Reproductive Medicine of Guangdong Province, Guangzhou 510080, 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