{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T02:29:50Z","timestamp":1785205790615,"version":"3.55.0"},"reference-count":63,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Inflammation"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Vitamin D plays a significant role in the immune system modulation and may confer a protective role in autoimmune diseases. We conducted a case-control study to compare 25(OH)D levels in patients with BD who were managed at a regional rheumatology programme in the midwest region of Ireland compared to matched controls. Healthy controls were selected from the Irish health system and matched in 1\u2009:\u20095 ratio for age, sex, and the month of the year. 25(OH)D levels &lt;20\u2009nmol\/L were classified as deficient while levels between 20 and 40\u2009nmol\/L were classified as insufficient. Differences between groups were assessed using Mann\u2013Whitney test and associations between cases and controls were expressed as odds ratios and 95% confidence intervals. Nineteen patients with BD were compared with 95 controls matched by age, sex, and month of blood draw. 25(OH)D levels were significantly higher in patients in BD than in matched controls (median values: 45\u2009nmol\/L versus 22\u2009nmol\/L, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.005<\/mml:mn><\/mml:math>) and tended to be lower in patients with active disease than in those without (median values: 35\u2009nmol\/L (IQR: 22.75\u201347.25\u2009nm\/L) versus 50\u2009nmol\/L (IQR: 35\u201367\u2009nmol\/L), <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.11<\/mml:mn><\/mml:math>). Compared to controls, patients with BD were significantly less likely to have 25(OH)D deficiency or insufficiency (OR: 0.09, 95% CI: 0.03\u20130.28, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>). Our findings suggest a possible role for 25(OH)D in modifying the inflammatory response in BD and uncover a potential opportunity to assess whether correction of Vit D deficiency confers protective benefits.<\/jats:p>","DOI":"10.1155\/2017\/8608716","type":"journal-article","created":{"date-parts":[[2017,6,4]],"date-time":"2017-06-04T17:03:34Z","timestamp":1496595814000},"page":"1-7","source":"Crossref","is-referenced-by-count":5,"title":["High Vitamin D Levels May Downregulate Inflammation in Patients with Beh\u00e7et\u2019s Disease"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9444-0810","authenticated-orcid":true,"given":"Fahd","family":"Adeeb","sequence":"first","affiliation":[{"name":"Department of Rheumatology, University Hospital Limerick, Limerick, Ireland"},{"name":"Graduate Entry Medical School, University of Limerick, Limerick, Ireland"},{"name":"Health Research Institute, University of Limerick, Ireland"},{"name":"Department of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Usman","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Hospital Limerick, Limerick, Ireland"},{"name":"Graduate Entry Medical School, University of Limerick, Limerick, Ireland"},{"name":"Health Research Institute, University of Limerick, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[{"name":"Graduate Entry Medical School, University of Limerick, Limerick, Ireland"},{"name":"Department of Mathematics and Statistics, La Trobe University, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin G.","family":"Stack","sequence":"additional","affiliation":[{"name":"Graduate Entry Medical School, University of Limerick, Limerick, Ireland"},{"name":"Health Research Institute, University of Limerick, Ireland"},{"name":"Department of Nephrology, University Hospital Limerick, Limerick, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Devlin","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Hospital Limerick, Limerick, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander D.","family":"Fraser","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Hospital Limerick, Limerick, Ireland"},{"name":"Graduate Entry Medical School, University of Limerick, Limerick, Ireland"},{"name":"Health Research Institute, University of Limerick, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1039\/C5PP00008D","volume":"14","year":"2015","journal-title":"Photochemical and Photobiological 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