{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T16:40:02Z","timestamp":1740156002672,"version":"3.37.3"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To evaluate the effect of the Rho-kinase inhibitor Y-27632 on postoperative inflammation and adhesion following extraocular muscle surgery in rabbits.<jats:italic>Methods<\/jats:italic>. The superior rectus muscle reinsertion was performed on both eyes of 8 New Zealand white rabbits. After reinsertion, the rabbits received subconjunctival injections of the Rho-kinase inhibitor and saline on each eye. To assess acute and late inflammatory changes, Ki-67, CD11<jats:italic>\u03b2<\/jats:italic>+, and F4\/80 were evaluated and the sites of muscle reattachment were evaluated for a postoperative adhesion score and histopathologically for collagen formation.<jats:italic>Results<\/jats:italic>. F4\/80 antibody expression was significantly different in the Rho-kinase inhibitor-injected group at both postoperative day 3 and week 4 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.038<\/mml:mn><\/mml:math>, 0.031). However, Ki-67 and CD11<jats:italic>\u03b2<\/jats:italic>+ were not different the between two groups. The difference in the SRM\/conjunctiva adhesion score between the two groups was also significant (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.034<\/mml:mn><\/mml:math>)<jats:italic>. Conclusion<\/jats:italic>. Intraoperative subconjunctival injection of the Rho-kinase inhibitor may be effective for adjunctive management of inflammation and fibrosis in rabbit eyes following extraocular muscle surgery.<\/jats:p>","DOI":"10.1155\/2017\/8653130","type":"journal-article","created":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T17:03:40Z","timestamp":1501088620000},"page":"1-8","source":"Crossref","is-referenced-by-count":0,"title":["Effects of the Rho-Kinase Inhibitor Y-27632 on Extraocular Muscle Surgery in Rabbits"],"prefix":"10.1155","volume":"2017","author":[{"given":"Ji\u2010Sun","family":"Moon","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Science, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, No. 222 Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of 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