{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:41:29Z","timestamp":1790617289584,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>The role of type I IFNs in the pathogenesis and control of mycobacterial infection is still controversial. It has been reported that type I IFNs exacerbated<jats:italic> M. tuberculosis<\/jats:italic> infection through hampering Th1 type cellular immune response. However, under certain conditions they can act as natural immune adjuvants for commercial vaccines. At this point, we have reported recently that successive IFN-alpha boosting of<jats:italic> Mycobacterium bovis Bacillus Calmette G\u00fcerin<\/jats:italic> (BCG) vaccinated mice protected adult mice from intradermal<jats:italic> M. lepraemurium<\/jats:italic> infection and a difference in iNOS was observed. In the present work, we have found that intramuscular IFN-<jats:italic>\u03b1<\/jats:italic> boosting of<jats:italic> Mycobacterium bovis Bacillus Calmette G\u00fcerin<\/jats:italic> (BCG) vaccine, either in vitro (human cell line or macrophages derived from PBMC) or in vivo (aerosol mouse model of<jats:italic> MTb<\/jats:italic> infection), promoted mostly the development of specific anti-antimycobacterial Th1 type cytokines (IFN-<jats:italic>\u03b3<\/jats:italic>; IL-12, TNF-alpha, and IL-17; IL1<jats:italic>\u03b2<\/jats:italic>) while bacterial load reduction (0.9 logs versus PBS or BCG vaccine) was observed. These findings indicate that, under the experimental settings reported here, interferon alpha can drive or affect the TH cellular immune response in favour of BCG-inducing immunity against<jats:italic> M. tuberculosis<\/jats:italic> infection.<\/jats:p>","DOI":"10.1155\/2017\/8796760","type":"journal-article","created":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T17:01:08Z","timestamp":1506531668000},"page":"1-8","source":"Crossref","is-referenced-by-count":19,"title":["IFN-<i>\u03b1<\/i> Boosting of<i> Mycobacterium bovis Bacillus<\/i> Calmette G\u00fcerin-Vaccine Promoted Th1 Type Cellular Response and Protection against<i> M. tuberculosis <\/i>Infection"],"prefix":"10.1155","volume":"2017","author":[{"given":"C. E.","family":"Rivas-Santiago","sequence":"first","affiliation":[{"name":"Unidad Acad\u00e9mica de Ciencias Biol\u00f3gicas, Laboratorio de Bioqu\u00edmica Molecular e Inmunobiologia, Universidad Aut\u00f3noma de Zacatecas, Av. Preparatoria S\/N. Col. Agron\u00f3micas, 98066 Zacatecas, ZAC, Mexico"},{"name":"Catedra-CONACYT, Avenida Insurgentes Sur 1685, Guadalupe Inn, 01020 \u00c1lvaro Obreg\u00f3n, CDMX, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4030-1783","authenticated-orcid":true,"given":"G. G.","family":"Guerrero","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Ciencias Biol\u00f3gicas, Laboratorio de Bioqu\u00edmica Molecular e Inmunobiologia, Universidad Aut\u00f3noma de Zacatecas, Av. Preparatoria S\/N. Col. 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