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No current therapy directly targets this process. We aimed to determine the effects of mannan derived from\n                    <jats:italic>S. cerevisiae<\/jats:italic>\n                    (SC-MN) on airway epithelial wound repair, in vitro\n                    <jats:italic>.<\/jats:italic>\n                    The presence of functional mannose receptors in bronchial epithelial cells was shown by endocytosis of colloidal gold-Man BSA via clathrin-coated pits in 16HBE cells. In primary normal human bronchial epithelial cells (NHBEC), SC-MN significantly facilitated wound closure. Treatment with SC-MN stimulated cell spreading as indicated by a significant increase in the average lamellipodial width of wound edge 16HBE cells. In addition, NHBEC treated with SC-MN showed increased expression and activation of Kr\u00fcppel-like factors (KLFs) 4 and 5, transcription factors important in epithelial cell survival and regulation of epithelial-mesenchymal transition. We conclude that SC-MN facilitates wound repair in human bronchial epithelium, involving mannose receptors.\n                  <\/jats:p>","DOI":"10.1155\/2017\/8903982","type":"journal-article","created":{"date-parts":[[2017,7,9]],"date-time":"2017-07-09T17:07:26Z","timestamp":1499620046000},"page":"1-7","source":"Crossref","is-referenced-by-count":16,"title":["Airway Epithelial Repair by a Prebiotic Mannan Derived from\n                    <i>Saccharomyces cerevisiae<\/i>"],"prefix":"10.1155","volume":"2017","author":[{"given":"Christie F.","family":"Michael","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Tennessee Health Science Center (UTHSC), Memphis, TN 38103, USA"},{"name":"Children\u2019s Foundation Research Institute, Le Bonheur Children\u2019s Hospital, Memphis, TN 38103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Waters","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Tennessee Health Science Center (UTHSC), Memphis, TN 38163, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim S.","family":"LeMessurier","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Tennessee Health Science Center (UTHSC), Memphis, TN 38103, USA"},{"name":"Children\u2019s Foundation Research Institute, Le Bonheur Children\u2019s Hospital, Memphis, TN 38103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amali E.","family":"Samarasinghe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Tennessee Health Science Center (UTHSC), Memphis, TN 38103, USA"},{"name":"Children\u2019s Foundation Research Institute, Le Bonheur Children\u2019s Hospital, Memphis, TN 38103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Y.","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Tennessee Health Science Center (UTHSC), Memphis, TN 38163, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kafait U.","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Tennessee Health Science Center (UTHSC), Memphis, TN 38163, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0857-5875","authenticated-orcid":true,"given":"D. 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