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A susceptible-exposed in the latent stage-infectious (SEI) model is established to sketch the evolution of epidemic. The basic reproduction number is defined. By constructing Lyapunov function, globally asymptotical stabilities of the disease-free and endemic equilibria are given. Then, optimal control theory is applied in HIV\/AIDS epidemic. Precaution, screening, and treatment of control variables are introduced and a new model with control is established. Through the HIV\/AIDS data in China, all parameters involved in SEI model are analyzed and parts of them are estimated. Further, by control model, optimal strategy is obtained. 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