{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T03:38:02Z","timestamp":1760499482418,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004681","name":"Higher Education Commission, Pakistan","doi-asserted-by":"publisher","award":["02100","NECT-13-0695","81102623"],"award-info":[{"award-number":["02100","NECT-13-0695","81102623"]}],"id":[{"id":"10.13039\/501100004681","id-type":"DOI","asserted-by":"publisher"}]},{"name":"New Century Excellent Talents of China","award":["02100","NECT-13-0695","81102623"],"award-info":[{"award-number":["02100","NECT-13-0695","81102623"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["02100","NECT-13-0695","81102623"],"award-info":[{"award-number":["02100","NECT-13-0695","81102623"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>The present study is focused on the assessment of the medicinal therapeutic potential extracts of<jats:italic> H. rosea<\/jats:italic> to investigate their pharmacological implications based upon science proofs. The antioxidant activity of fraction of<jats:italic> H. rosea<\/jats:italic>, namely, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>n<\/mml:mi><\/mml:mrow><\/mml:math>-hexane (HR-1), ethyl acetate (HR-2), chloroform (HR-3), and <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>n<\/mml:mi><\/mml:mrow><\/mml:math>-butanol (HR-4), was performed by using the DPPH radical scavenging method. The cytotoxicity and enzyme inhibition assessment were also performed. All the extracts showed significant antioxidant, antibacterial, and protein kinase inhibition but none of the extracts exhibited <jats:italic>\u03b1<\/jats:italic>-amylase inhibition activity. The chloroform extract HR-3 may block a kinase receptor from binding to ATP; the lead molecule will be isolated, which may stop cancerous cell growth and demotion of cell division. It is predicted that ethyl acetate, chloroform, and <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>n<\/mml:mi><\/mml:mrow><\/mml:math>-butanol extracts of<jats:italic> H. rosea<\/jats:italic> contain polyphenolics, flavonoids, and alkaloids that are biologically effective candidates exhibiting significant cytotoxicity, antioxidant, and antimicrobial activities. They may control oxidative damage in the body tissues and act as potential antidiabetic and anticancer agents. These studies will also be helpful for future drug designing and drug development research.<\/jats:p>","DOI":"10.1155\/2017\/8968604","type":"journal-article","created":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T18:31:20Z","timestamp":1512412280000},"page":"1-8","source":"Crossref","is-referenced-by-count":5,"title":["<i>In Vitro<\/i> Biological Screening of<i> Hartmannia rosea<\/i> Extracts"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3913-268X","authenticated-orcid":true,"given":"Rehana","family":"Rashid","sequence":"first","affiliation":[{"name":"Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1620-975X","authenticated-orcid":true,"given":"Abida","family":"Kalsoom Khan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, COMSATS Institute of Information Technology, 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