{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:59:06Z","timestamp":1790395146953,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infectious Diseases in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. To investigate whether maternal oral flora might be involved in intrauterine infection and subsequent stillbirth or neonatal death and could therefore be detected in fetal and neonatal postmortem bacterial cultures.<jats:italic>Methods<\/jats:italic>. This retrospective study of postmortem examinations from 1\/1\/2000 to 12\/31\/2010 was searched for bacterial cultures positive for common oral flora from heart blood or lung tissue. Maternal age, gestational age, age at neonatal death, and placental and fetal\/neonatal histopathological findings were collected.<jats:italic>Results<\/jats:italic>. During the study period 1197 postmortem examinations (861 stillbirths and 336 neonatal deaths) were performed in our hospital with gestational ages ranging from 13 to 40+ weeks. Cultures positive for oral flora were identified in 24 autopsies including 20 pure and 8 mixed growths (26\/227, 11.5%), found in 16 stillbirths and 8 neonates. Microscopic examinations of these 16 stillbirths revealed 8 with features of infection and inflammation in fetus and placenta. The 7 neonatal deaths within 72 hours after birth grew 6 pure isolates and 1 mixed, and 6 correlated with fetal and placental inflammation.<jats:italic>Conclusions<\/jats:italic>. Pure isolates of oral flora with histological evidence of inflammation\/infection in the placenta and fetus or infant suggest a strong association between maternal periodontal conditions and perinatal death.<\/jats:p>","DOI":"10.1155\/2017\/9027918","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T18:30:37Z","timestamp":1487874637000},"page":"1-9","source":"Crossref","is-referenced-by-count":5,"title":["Perinatal Mortality Associated with Positive Postmortem Cultures for Common Oral Flora"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4775-9757","authenticated-orcid":true,"given":"Mai","family":"He","sequence":"first","affiliation":[{"name":"Department of Pathology & Laboratory Medicine, Women & Infants Hospital of Rhode Island, Providence, RI, USA"},{"name":"Department of Pathology & Laboratory Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA"},{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison R.","family":"Migliori","sequence":"additional","affiliation":[{"name":"Department of Pathology & Laboratory Medicine, Women & Infants Hospital of Rhode Island, Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Lauro","sequence":"additional","affiliation":[{"name":"Department of Pathology & Laboratory Medicine, Women & Infants Hospital of Rhode Island, Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. James","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Pathology & Laboratory Medicine, Women & Infants Hospital of Rhode Island, Providence, RI, USA"},{"name":"Department of Pathology & Laboratory Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halit","family":"Pinar","sequence":"additional","affiliation":[{"name":"Department of Pathology & Laboratory Medicine, Women & Infants Hospital of Rhode Island, Providence, RI, USA"},{"name":"Department of Pathology & Laboratory Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"22","key":"1","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1001\/jama.2011.1823","volume":"306","year":"2011","journal-title":"The Journal of the American Medical Association"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005183422007"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/737425"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2011.09.001"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2005.00827.x"},{"issue":"1","key":"7","first-page":"34","volume":"32","year":"2011","journal-title":"Neuroendocrinology Letters"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-010-1774-9"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181cb9955"},{"issue":"9","key":"10","first-page":"379","volume":"58","year":"1980","journal-title":"South African Medical Journal"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31816a49d3"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-005-0010-2"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000139836.47777.6d"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-9-s1-s4"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2009.00953.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1284228"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02419.x"},{"issue":"6","key":"18","first-page":"473","volume":"14","year":"1994","journal-title":"Journal of Perinatology"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1002\/1098-0997(2000)8:560;220::aid-idog102262;3.0.co;2-i"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1080\/00365549850160873"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.3109\/15513819109064743"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1080\/10647440300025508"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2014.11.013"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2012\/4609.2540"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080012"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1998.3.1.222"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008599"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.44.4.1475-1483.2006"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003056"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01206-08"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.2217\/whe.11.37"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.2350\/10-03-0804-CR.1"}],"container-title":["Infectious Diseases in Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/idog\/2017\/9027918.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/idog\/2017\/9027918.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/idog\/2017\/9027918.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T07:15:07Z","timestamp":1498374907000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/idog\/2017\/9027918\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":31,"alternative-id":["9027918","9027918"],"URL":"https:\/\/doi.org\/10.1155\/2017\/9027918","relation":{},"ISSN":["1064-7449","1098-0997"],"issn-type":[{"value":"1064-7449","type":"print"},{"value":"1098-0997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}