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High-molecular-weight adiponectin (HMWA) was proposed as the most biologically active form of this insulin-sensitizing adipokine. There are no studies assessing the relative merits of leptin\/HMWA ratio over LAR as a biomarker of systemic insulin sensitivity. A standard 2-hour oral glucose tolerance test (OGTT; 75\u2009g of glucose) and a short minimal-model intravenous glucose tolerance test (IVGTT; 0.3\u2009g\/kg body weight) were performed in 58 Chilean normoglycemic women (age: 27\u2009\u00b1\u20096.3 years, BMI 23.6\u2009\u00b1\u20093.2\u2009kg\/m<jats:sup>2<\/jats:sup>). LAR was negatively associated with HOMA-S (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>\u2212<\/mml:mo><mml:mn>0.49<\/mml:mn><\/mml:math>; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.0001<\/mml:mn><\/mml:math>), Matsuda-ISICOMP (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>\u2212<\/mml:mo><mml:mn>0.54<\/mml:mn><\/mml:math>; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.0001<\/mml:mn><\/mml:math>), and the calculated sensitivity index (CSi) derived from IVGTT (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>\u2212<\/mml:mo><mml:mn>0.38<\/mml:mn><\/mml:math>; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.007<\/mml:mn><\/mml:math>). In comparison to LAR, leptin\/HMWA ratio did not increase neither the linear fit (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:msup><mml:mrow><mml:mi>r<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn>2<\/mml:mn><\/mml:mrow><\/mml:msup><\/mml:math>) nor the magnitude of association with insulin sensitivity indexes (slope of multiple linear regression). The discriminatory capacity of both ratios to classify insulin-resistant versus insulin-sensitive subjects was similar for HOMA-S (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.84<\/mml:mn><\/mml:math>), Matsuda-ISICOMP (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.43<\/mml:mn><\/mml:math>), or CSi (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.50<\/mml:mn><\/mml:math>). In conclusion, LAR showed consistent negative associations with different systemic insulin sensitivity indexes. The use of HMWA to generate leptin\/HMWA ratio did not show any advantage over LAR as a biomarker of systemic insulin sensitivity in normoglycemic women.<\/jats:p>","DOI":"10.1155\/2017\/9031079","type":"journal-article","created":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T17:01:36Z","timestamp":1495731696000},"page":"1-11","source":"Crossref","is-referenced-by-count":19,"title":["Leptin\/Adiponectin Ratios Using Either Total Or High-Molecular-Weight Adiponectin as Biomarkers of Systemic Insulin Sensitivity in Normoglycemic Women"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6712-2430","authenticated-orcid":true,"given":"Carolina","family":"Bravo","sequence":"first","affiliation":[{"name":"Department of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, 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