{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:57:40Z","timestamp":1792799860404,"version":"4.5.0"},"reference-count":186,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T00:00:00Z","timestamp":1511395200000},"content-version":"vor","delay-in-days":326,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Chronic kidney disease (CKD) patients are among the groups at the highest risk for cardiovascular disease and significantly shortened remaining lifespan. CKD enhances oxidative stress in the organism with ensuing cardiovascular damage. Oxidative stress in uremia is the consequence of higher reactive oxygen species (ROS) production, whereas attenuated clearance of pro\u2010oxidant substances and impaired antioxidant defenses play a complementary role. The pathophysiological mechanism underlying the increased ROS production in CKD is at least partly mediated by upregulation of the intrarenal angiotensin system. Enhanced oxidative stress in the setting of the uremic milieu promotes enzymatic modification of circulating lipids and lipoproteins, protein carbamylation, endothelial dysfunction via disruption of nitric oxide (NO) pathways, and activation of inflammation, thus accelerating atherosclerosis. Left ventricular hypertrophy (LVH) and heart failure are hallmarks of CKD. NADPH oxidase activation, xanthine oxidase, mitochondrial dysfunction, and NO\u2010ROS are the main oxidative pathways leading to LVH and the cardiorenal syndrome. Finally, a subset of antioxidant enzymes, the paraoxonases (PON), deserves special attention due to abundant clinical evidence accumulated regarding reduced serum PON1 activity in CKD as a contributor to the increased burden of cardiovascular disease. Future, meticulously designed studies are needed to assess the effects of antioxidant therapy on patients with CKD.<\/jats:p>","DOI":"10.1155\/2017\/9036450","type":"journal-article","created":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T23:31:52Z","timestamp":1511479912000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":109,"title":["Chronic Kidney Disease and Disproportionally Increased Cardiovascular Damage: Does Oxidative Stress Explain the Burden?"],"prefix":"10.1155","volume":"2017","author":[{"given":"Anila","family":"Duni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7564-2724","authenticated-orcid":false,"given":"Vassilios","family":"Liakopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolos-Pavlos","family":"Rapsomanikis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1172-1829","authenticated-orcid":false,"given":"Evangelia","family":"Dounousi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,23]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c4986"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025920"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.536"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/kisup.2011.7"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.10.009"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.018713"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60595-4"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.678342"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000417"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03670807"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.516"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2012.01572.x"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg074"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.09.029"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2016.05.036"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.08.015"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2004.06.026"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.123638"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.175828"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012111112"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxins8120376"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2012.749302"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn489"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(01)07217-8"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.439"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00421.2009"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.278.4.F676"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000077412.07578.44"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00221.2004"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.asn.0000077410.66390.0f"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7047238"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000138070.47616.9d"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000198"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2016.08.004"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI80761"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/806358"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.04.005"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.09913.x"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.309326"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000133604.20182.cf"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00047.2003"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2558"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.07.024"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2006.01.001"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.09.001"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.196592"},{"key":"e_1_2_9_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.307843"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2013.07.006"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000163262.83456.6d"},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.7.1716"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200401293500519"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.03.168"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/152786"},{"key":"e_1_2_9_54_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.03.047"},{"key":"e_1_2_9_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12049"},{"key":"e_1_2_9_56_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20130369"},{"key":"e_1_2_9_57_2","first-page":"640","article-title":"Myeloperoxidase and progression of aortic valve stenosis in patients undergoing hemodialysis","volume":"22","author":"Wada S.","year":"2013","journal-title":"The Journal of Heart Valve Disease"},{"key":"e_1_2_9_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.07.011"},{"key":"e_1_2_9_59_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/971579"},{"key":"e_1_2_9_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.10.038"},{"key":"e_1_2_9_61_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.303454"},{"key":"e_1_2_9_62_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010111144"},{"key":"e_1_2_9_63_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001689"},{"key":"e_1_2_9_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.09.013"},{"key":"e_1_2_9_65_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013111212"},{"key":"e_1_2_9_66_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013111219"},{"key":"e_1_2_9_67_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016030262"},{"key":"e_1_2_9_68_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu111"},{"key":"e_1_2_9_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.07.755"},{"key":"e_1_2_9_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2010.10.098"},{"key":"e_1_2_9_71_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3640"},{"key":"e_1_2_9_72_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu122"},{"key":"e_1_2_9_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.166"},{"key":"e_1_2_9_74_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3005218"},{"key":"e_1_2_9_75_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012030254"},{"key":"e_1_2_9_76_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010040365"},{"key":"e_1_2_9_77_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2011.10.023"},{"key":"e_1_2_9_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1637"},{"key":"e_1_2_9_79_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000340"},{"key":"e_1_2_9_80_2","doi-asserted-by":"publisher","DOI":"10.1159\/000299798"},{"key":"e_1_2_9_81_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05340610"},{"key":"e_1_2_9_82_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-017-0457-1"},{"key":"e_1_2_9_83_2","doi-asserted-by":"publisher","DOI":"10.1159\/000098542"},{"key":"e_1_2_9_84_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132589"},{"key":"e_1_2_9_85_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171561"},{"key":"e_1_2_9_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.09.024"},{"key":"e_1_2_9_87_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpu225"},{"key":"e_1_2_9_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(01)00610-4"},{"key":"e_1_2_9_89_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl564"},{"key":"e_1_2_9_90_2","doi-asserted-by":"publisher","DOI":"10.1159\/000081731"},{"key":"e_1_2_9_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.09.052"},{"key":"e_1_2_9_92_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000330"},{"key":"e_1_2_9_93_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00239.x"},{"key":"e_1_2_9_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2012.02.001"},{"key":"e_1_2_9_95_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000035250.66458.67"},{"key":"e_1_2_9_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.01.020"},{"key":"e_1_2_9_97_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2011.00568.x"},{"key":"e_1_2_9_98_2","doi-asserted-by":"publisher","DOI":"10.1159\/000076244"},{"key":"e_1_2_9_99_2","doi-asserted-by":"publisher","DOI":"10.1159\/000085290"},{"key":"e_1_2_9_100_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr443"},{"key":"e_1_2_9_101_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm906"},{"key":"e_1_2_9_102_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/835465"},{"key":"e_1_2_9_103_2","doi-asserted-by":"publisher","DOI":"10.1159\/000057601"},{"key":"e_1_2_9_104_2","doi-asserted-by":"publisher","DOI":"10.1159\/000100419"},{"key":"e_1_2_9_105_2","doi-asserted-by":"publisher","DOI":"10.5414\/CNP68144"},{"key":"e_1_2_9_106_2","doi-asserted-by":"publisher","DOI":"10.1159\/000135655"},{"key":"e_1_2_9_107_2","doi-asserted-by":"publisher","DOI":"10.4103\/0971-4065.75218"},{"key":"e_1_2_9_108_2","doi-asserted-by":"publisher","DOI":"10.5301\/JN.2011.6442"},{"key":"e_1_2_9_109_2","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2011-0775"},{"key":"e_1_2_9_110_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/18.1.106"},{"key":"e_1_2_9_111_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh035"},{"key":"e_1_2_9_112_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2011.10.019"},{"key":"e_1_2_9_113_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070822"},{"key":"e_1_2_9_114_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01110113"},{"key":"e_1_2_9_115_2","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2013.00259"},{"key":"e_1_2_9_116_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2010.00841.x"},{"key":"e_1_2_9_117_2","doi-asserted-by":"publisher","DOI":"10.1159\/000320201"},{"key":"e_1_2_9_118_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008176.pub2"},{"key":"e_1_2_9_119_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm542"},{"key":"e_1_2_9_120_2","doi-asserted-by":"publisher","DOI":"10.5301\/JN.2010.2030"},{"key":"e_1_2_9_121_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.06020612"},{"key":"e_1_2_9_122_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2008.00454.x"},{"key":"e_1_2_9_123_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.35"},{"key":"e_1_2_9_124_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00530.x"},{"key":"e_1_2_9_125_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.02.376"},{"key":"e_1_2_9_126_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.07.051"},{"key":"e_1_2_9_127_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2002.1526"},{"key":"e_1_2_9_128_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000032031.30374.32"},{"key":"e_1_2_9_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2008.06.006"},{"key":"e_1_2_9_130_2","doi-asserted-by":"publisher","DOI":"10.1080\/15257771003738683"},{"key":"e_1_2_9_131_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000254415.31362.a7"},{"key":"e_1_2_9_132_2","doi-asserted-by":"publisher","DOI":"10.1161\/hh1701.096615"},{"key":"e_1_2_9_133_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms141123011"},{"key":"e_1_2_9_134_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-013-0359-8"},{"key":"e_1_2_9_135_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2828(03)00084-1"},{"key":"e_1_2_9_136_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000021430.04195.51"},{"key":"e_1_2_9_137_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00471-6"},{"key":"e_1_2_9_138_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03402088"},{"key":"e_1_2_9_139_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0214190"},{"key":"e_1_2_9_140_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.173328"},{"key":"e_1_2_9_141_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2000.1285"},{"key":"e_1_2_9_142_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000109412.80157.7D"},{"key":"e_1_2_9_143_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000115557.25127.8D"},{"key":"e_1_2_9_144_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio1364"},{"key":"e_1_2_9_145_2","doi-asserted-by":"publisher","DOI":"10.2174\/1570161054368607"},{"key":"e_1_2_9_146_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.109.888479"},{"key":"e_1_2_9_147_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2011.08.008"},{"key":"e_1_2_9_148_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-012-9330-2"},{"key":"e_1_2_9_149_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.232306"},{"key":"e_1_2_9_150_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7520231"},{"key":"e_1_2_9_151_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.429"},{"key":"e_1_2_9_152_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfr093"},{"key":"e_1_2_9_153_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2006.04.003"},{"key":"e_1_2_9_154_2","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e3182239eb7"},{"key":"e_1_2_9_155_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.08.1021"},{"key":"e_1_2_9_156_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2014.06.008"},{"key":"e_1_2_9_157_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.115.002639"},{"key":"e_1_2_9_158_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048590"},{"key":"e_1_2_9_159_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.11.017"},{"key":"e_1_2_9_160_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.06.054"},{"key":"e_1_2_9_161_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-350-3_11"},{"key":"e_1_2_9_162_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms151120997"},{"key":"e_1_2_9_163_2","first-page":"226","article-title":"The role of paraoxonase in cardiovascular diseases","volume":"45","author":"Shih D. M.","year":"2015","journal-title":"Annals of Clinical and Laboratory Science"},{"key":"e_1_2_9_164_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M910376199"},{"key":"e_1_2_9_165_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42946"},{"key":"e_1_2_9_166_2","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.08-255"},{"key":"e_1_2_9_167_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.11320"},{"key":"e_1_2_9_168_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.253930"},{"key":"e_1_2_9_169_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.12.021"},{"key":"e_1_2_9_170_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.11.1265"},{"key":"e_1_2_9_171_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15642-0"},{"key":"e_1_2_9_172_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V9112082"},{"key":"e_1_2_9_173_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2010.00844.x"},{"key":"e_1_2_9_174_2","first-page":"131","article-title":"Paraoxonase 1 arylesterase activity and mass are reduced and inversely related to C-reactive protein in patients on either standard or home nocturnal hemodialysis","volume":"73","author":"Kannampuzha J.","year":"2010","journal-title":"Clinical Nephrology"},{"key":"e_1_2_9_175_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/726048"},{"key":"e_1_2_9_176_2","doi-asserted-by":"publisher","DOI":"10.5414\/cnp67358"},{"key":"e_1_2_9_177_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.112.000104"},{"key":"e_1_2_9_178_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-016-0131-4"},{"key":"e_1_2_9_179_2","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2010.10"},{"key":"e_1_2_9_180_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000786"},{"key":"e_1_2_9_181_2","doi-asserted-by":"publisher","DOI":"10.3109\/10641963.2016.1174255"},{"key":"e_1_2_9_182_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.110.958348"},{"key":"e_1_2_9_183_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.07.045"},{"key":"e_1_2_9_184_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hft084"},{"key":"e_1_2_9_185_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1507270"},{"key":"e_1_2_9_186_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.9175"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2017\/9036450.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2017\/9036450.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2017\/9036450","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T04:56:16Z","timestamp":1722920176000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2017\/9036450"}},"subtitle":[],"editor":[{"given":"Ryuichi","family":"Morishita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":186,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1155\/2017\/9036450"],"URL":"https:\/\/doi.org\/10.1155\/2017\/9036450","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"2017-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9036450"}}