{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:22:22Z","timestamp":1780514542911,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Several studies have shown that dexmedetomidine (DXM), a selective <jats:italic>\u03b1<\/jats:italic>2-adrenoceptor agonist, also has neuroprotective effects. However, its effect on impaired peripheral nerve regeneration has not been studied. <jats:italic>Materials and Methods<\/jats:italic>. Forty-five Sprague-Dawley rats were randomly assigned to three groups: group 1 (control SHAM), group 2 (sciatic nerve injury\u2009+\u2009normal saline), and group 3 (sciatic nerve injury\u2009+\u2009DXM). The rats of group 3 were subdivided into the following three groups: DXM 0.5, 6, and 20\u2009<jats:italic>\u03bc<\/jats:italic>g\u00b7kg<jats:sup>\u22121<\/jats:sup> (groups 3A, 3B, and 3C, resp.). The sciatic nerve injury was assessed for nerve regeneration at 2 and 6 weeks. <jats:italic>Results<\/jats:italic>. There were no differences between groups 2 and 3 in their sciatic functional index (SFI) values or histological findings at 2 weeks postinjury. However, SFI differences were statistically significant at 6 weeks postinjury in group 3. The gross findings with H&amp;E staining showed that the number of axons was higher in group 3 than in group 2. There was no histological difference according to the DXM concentration. <jats:italic>Conclusion<\/jats:italic>. The coincidental functional and histological assessment results of this study suggest that DXM for 6 weeks positively affects damaged peripheral nerves.<\/jats:p>","DOI":"10.1155\/2017\/9045608","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T18:31:46Z","timestamp":1513189906000},"page":"1-7","source":"Crossref","is-referenced-by-count":8,"title":["Dexmedetomidine to Help Nerve Regeneration in a Rat Sciatic Nerve Injury Model"],"prefix":"10.1155","volume":"2017","author":[{"given":"Wook","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Suryeoan Clinic, Busan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsichiang","family":"Kung","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Kosin University College of Medicine, Busan, Republic of 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