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Cranial CT scan and MRI showed an ethmoid mass extending to the choanal region, the right orbit, and the right frontal sinus with an initial intracranial extension. Patient underwent surgery with a trans-sinusal frontal approach using a bicoronal incision combined with an anterior midfacial degloving; histological exam was compatible with a metastasis of clear cell renal cell carcinoma. Following histological findings, a total body CT scan showed a solitary 6\u2009cm mass in the upper posterior pole of the left kidney identified as the primary tumor. Although rare, metastatic renal cell carcinoma should always be suspected in patients with nasal or paranasal masses, especially if associated with symptoms suggestive of a systemic involvement such as hematuria. A correct early-stage diagnosis of metastatic RCC can considerably improve survival rate in these patients; preoperative differential diagnosis with contrast-enhanced imaging is fundamental for the correct treatment and follow-up strategy.<\/jats:p>","DOI":"10.1155\/2017\/9242374","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T21:09:14Z","timestamp":1484168954000},"page":"1-5","source":"Crossref","is-referenced-by-count":5,"title":["Metastatic Renal Cell Carcinoma Presenting as a Paranasal Sinus Mass: The Importance of Differential Diagnosis"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8776-0421","authenticated-orcid":true,"given":"Massimo","family":"Ralli","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, 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