{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:44:29Z","timestamp":1773211469312,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T00:00:00Z","timestamp":1491177600000},"content-version":"vor","delay-in-days":92,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2012 R1A5A2A42671316"],"award-info":[{"award-number":["2012 R1A5A2A42671316"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>The<jats:italic>Buddleja officinalis<\/jats:italic>Maxim. flower is used in traditional Chinese and Korean medicine to treat inflammation, vascular diseases, headache, and stroke, as well as enhance liver function. This research investigated the effects of<jats:italic>B. officinalis<\/jats:italic>Maxim. flower extract (BFE) on hepatotoxicity. The cytoprotective effects and mechanism of BFE against severe mitochondrial dysfunction and H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>production in hepatotoxicity induced by coadministration of arachidonic acid (AA) and iron were observed in the HepG2 cell line. In addition, we performed blood biochemical, histopathological, and histomorphometric analyses of mice with carbon tetrachloride\u2010 (CCl<jats:sub>4<\/jats:sub>\u2010) induced acute liver damage. BFE inhibited the AA + iron\u2010mediated hepatotoxicity of HepG2 cells. Moreover, it inhibited mitochondrial dysfunction, H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>production, and glutathione depletion mediated by AA + iron in the same cells. Meanwhile, the cytoprotective effects of BFE against oxidative stress were associated with the activation of AMP\u2010activated protein kinase (AMPK). In particular, based on the histopathological observations, BFE (30 and 100\u2009mg\/kg) showed clear hepatoprotective effects against CCl<jats:sub>4<\/jats:sub>\u2010induced acute hepatic damage. Furthermore, it inhibited 4\u2010hydroxynonenal and nitrotyrosine immunoreactivity in hepatocytes. These results provide evidence that BFE has beneficial hepatoprotective effects against hepatic damage via the activation of AMPK pathway. Accordingly, BFE may have therapeutic potential for diverse liver disorders.<\/jats:p>","DOI":"10.1155\/2017\/9253462","type":"journal-article","created":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T22:29:22Z","timestamp":1491258562000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Activation of AMPK by<i>Buddleja officinalis<\/i>Maxim. 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