{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T06:05:02Z","timestamp":1780380302360,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic> Chronic neonatal pain can lead to long-term adverse effects on the immature brain. EDIN scale for prolonged pain might not be fully suitable for premature infants. We aimed to test a modified EDIN scale, adding postmenstrual age (PMA) as a sixth item (EDIN6).<jats:italic> Methods.<\/jats:italic> In a two-phase prospective study, pain was assessed in all neonates admitted in our NICU. In <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>T<\/mml:mi><\/mml:mrow><\/mml:math>1 EDIN was applied; in <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>T<\/mml:mi><\/mml:mrow><\/mml:math>2 EDIN6 with additional scores of 2, 1, and 0, respectively, for 25\u201332, 33\u201337, and &gt;37 weeks PCA was tested. Scores &gt; 6 suggested pain. The nursing staff was given a questionnaire to evaluate EDIN and EDIN6.<jats:italic> Results.<\/jats:italic> A total of 15960 pain assessments were recorded (8693 in <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>T<\/mml:mi><\/mml:mrow><\/mml:math>1; 7267 in <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>T<\/mml:mi><\/mml:mrow><\/mml:math>2). With EDIN6, cumulative detection of pain almost tripled (117\/7267 versus 52\/8693, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>). Main differences were found among less mature categories (50\/1472 versus 17\/1734, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math> in PCA 25\u201332; 26\/2606 versus 10\/4335, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math> in PMA 33\u201337; 41\/3189 versus 25\/2624, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.26<\/mml:mn><\/mml:math> in PMA &gt; 37). Adequacy of pain assessment in lower PMA was judged \u201cmedium-high\u201d in 13,4% of nurses in <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mrow><mml:mi>T<\/mml:mi><\/mml:mrow><\/mml:math>1 and 71,4% in <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mrow><mml:mi>T<\/mml:mi><\/mml:mrow><\/mml:math>2.<jats:italic> Conclusions.<\/jats:italic> EDIN6 may allow improved evaluation of pain in preterm infants.<\/jats:p>","DOI":"10.1155\/2017\/9253710","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T16:03:01Z","timestamp":1486569781000},"page":"1-8","source":"Crossref","is-referenced-by-count":13,"title":["EDIN Scale Implemented by Gestational Age for Pain Assessment in Preterms: A Prospective 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