{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:25:20Z","timestamp":1740144320053,"version":"3.37.3"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Danish Council for Independent Research, Technology and Production Sciences","award":["0602-01911B (11-107077)"],"award-info":[{"award-number":["0602-01911B (11-107077)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contrast Media &amp; Molecular Imaging"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Positron emission tomography (PET) is increasingly applied for infection imaging using [<jats:sup>18<\/jats:sup>F]FDG as tracer, but uptake is unspecific. The present study compares the kinetics of [<jats:sup>18<\/jats:sup>F]FDG and three other PET tracers with relevance for infection imaging.<jats:italic> Methods<\/jats:italic>. A juvenile porcine osteomyelitis model was used. Eleven pigs underwent PET\/CT with 60-minute dynamic PET imaging of [<jats:sup>18<\/jats:sup>F]FDG, [<jats:sup>68<\/jats:sup>Ga]Ga-citrate, [<jats:sup>11<\/jats:sup>C]methionine, and\/or [<jats:sup>11<\/jats:sup>C]donepezil, along with blood sampling. For infectious lesions, kinetic modelling with one- and two-tissue-compartment models was conducted for each tracer.<jats:italic> Results<\/jats:italic>. Irreversible uptake was found for [<jats:sup>18<\/jats:sup>F]FDG and [<jats:sup>68<\/jats:sup>Ga]Ga-citrate; reversible uptake was found for [<jats:sup>11<\/jats:sup>C]methionine (two-tissue model) and [<jats:sup>11<\/jats:sup>C]donepezil (one-tissue model). The uptake rate for [<jats:sup>68<\/jats:sup>Ga]Ga-citrate was slow and diffusion-limited. For the other tracers, the uptake rate was primarily determined by perfusion (flow-limited uptake). Net uptake rate for [<jats:sup>18<\/jats:sup>F]FDG and distribution volume for [<jats:sup>11<\/jats:sup>C]methionine were significantly higher for infectious lesions than for correspondingly noninfected tissue. For [<jats:sup>11<\/jats:sup>C]donepezil in pigs, labelled metabolite products appeared to be important for the analysis.<jats:italic> Conclusions<\/jats:italic>. The kinetics of the four studied tracers in infection was characterized. For clinical applications, [<jats:sup>18<\/jats:sup>F]FDG remains the first-choice PET tracer. [<jats:sup>11<\/jats:sup>C]methionine may have a potential for detecting soft tissue infections. [<jats:sup>68<\/jats:sup>Ga]Ga-citrate and [<jats:sup>11<\/jats:sup>C]donepezil were not found useful for imaging of osteomyelitis.<\/jats:p>","DOI":"10.1155\/2017\/9256858","type":"journal-article","created":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T17:01:18Z","timestamp":1507568478000},"page":"1-18","source":"Crossref","is-referenced-by-count":5,"title":["Kinetic Modelling of Infection Tracers [<sup>18<\/sup>F]FDG, [<sup>68<\/sup>Ga]Ga-Citrate, [<sup>11<\/sup>C]Methionine, and [<sup>11<\/sup>C]Donepezil in a Porcine Osteomyelitis Model"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6811-0172","authenticated-orcid":true,"given":"Lars","family":"J\u00f8dal","sequence":"first","affiliation":[{"name":"Department of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Nuclear Medicine, Aalborg University Hospital, Aalborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svend B.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Aalborg University Hospital, Aalborg, Denmark"},{"name":"Department of Chemistry and Biosciences, Aalborg University, Aalborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole L.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1512-4981","authenticated-orcid":true,"given":"Pia","family":"Afzelius","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, North Zealand Hospital, Copenhagen University Hospital, Hiller\u00f8d, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Borghammer","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aage K. 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