{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:47:22Z","timestamp":1767167242031,"version":"build-2238731810"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672086"],"award-info":[{"award-number":["81672086"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["162yw01"],"award-info":[{"award-number":["162yw01"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Plan of Taizhou City","award":["81672086"],"award-info":[{"award-number":["81672086"]}]},{"name":"Science and Technology Plan of Taizhou City","award":["162yw01"],"award-info":[{"award-number":["162yw01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>\n                    <jats:italic>Objective.<\/jats:italic>\n                    Current studies of serum sclerostin levels in AS and RA patients are inconsistent. This meta-analysis was performed to identify the association of serum sclerostin level with AS and RA patients.\n                    <jats:italic>Methods.<\/jats:italic>\n                    Embase, PubMed, MEDLINE, and Cochrane Library databases (up to 25 January 2017) were used to collect all relevant published articles. Studies were pooled and standard mean difference (SMD) with 95% confidence interval (CI) was calculated. All data analyses were performed using RevMan 5.3.\n                    <jats:italic>Results.<\/jats:italic>\n                    Totally eight studies of AS including 420 AS patients and 317 healthy controls (HC) and three studies of RA including 145\u2009RA patients and 127\u2009HC were finally included in this meta-analysis. The results revealed that the serum sclerostin levels in both AS patients (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mi mathvariant=\"normal\">S<\/mml:mi>\n                      <mml:mi mathvariant=\"normal\">M<\/mml:mi>\n                      <mml:mi mathvariant=\"normal\">D<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mo>-<\/mml:mo>\n                      <mml:mn mathvariant=\"normal\">0.14<\/mml:mn>\n                    <\/mml:math>\n                    ; 95%\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                      <mml:mi mathvariant=\"normal\">C<\/mml:mi>\n                      <mml:mi mathvariant=\"normal\">I<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mo stretchy=\"false\">[<\/mml:mo>\n                      <mml:mo>-<\/mml:mo>\n                      <mml:mn mathvariant=\"normal\">0.39,0.11<\/mml:mn>\n                      <mml:mo stretchy=\"false\">]<\/mml:mo>\n                    <\/mml:math>\n                    ;\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">0.28<\/mml:mn>\n                    <\/mml:math>\n                    ) and RA patients (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                      <mml:mi mathvariant=\"normal\">S<\/mml:mi>\n                      <mml:mi mathvariant=\"normal\">M<\/mml:mi>\n                      <mml:mi mathvariant=\"normal\">D<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mo>-<\/mml:mo>\n                      <mml:mn mathvariant=\"normal\">0.10<\/mml:mn>\n                    <\/mml:math>\n                    ; 95%\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                      <mml:mi mathvariant=\"normal\">C<\/mml:mi>\n                      <mml:mi mathvariant=\"normal\">I<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mo stretchy=\"false\">[<\/mml:mo>\n                      <mml:mo>-<\/mml:mo>\n                      <mml:mn mathvariant=\"normal\">0.34,0.15<\/mml:mn>\n                      <mml:mo stretchy=\"false\">]<\/mml:mo>\n                    <\/mml:math>\n                    ;\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">0.43<\/mml:mn>\n                    <\/mml:math>\n                    ) were not significantly different from those in HC.\n                    <jats:italic>Conclusion.<\/jats:italic>\n                    The difference of serum sclerostin levels in AS and RA patients was not significantly different from HC, indicating that the sclerostin may not associate with the development of AS and RA.\n                  <\/jats:p>","DOI":"10.1155\/2017\/9295313","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T17:01:11Z","timestamp":1493830871000},"page":"1-7","source":"Crossref","is-referenced-by-count":11,"title":["Serum Sclerostin Levels in Patients with Ankylosing Spondylitis and Rheumatoid Arthritis: A Systematic Review and Meta-Analysis"],"prefix":"10.1155","volume":"2017","author":[{"given":"Jianfeng","family":"Shi","sequence":"first","affiliation":[{"name":"Wenzhou Medical University, Wenzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijian","family":"Ying","sequence":"additional","affiliation":[{"name":"Wenzhou Medical University, Wenzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juping","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Taizhou Hospital, Wenzhou Medical University, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1662-3558","authenticated-orcid":true,"given":"Bo","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Taizhou Hospital, Wenzhou Medical University, Zhejiang, 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