{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T04:23:57Z","timestamp":1778041437596,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,31]],"date-time":"2017-12-31T00:00:00Z","timestamp":1514678400000},"content-version":"vor","delay-in-days":364,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773335"],"award-info":[{"award-number":["81773335"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY15C070001"],"award-info":[{"award-number":["LY15C070001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Antroquinonol was investigated as antioxidant and inhibition of inflammatory responses. Our study was to evaluate its immunosuppressive effect on CD8<jats:sup>+<\/jats:sup> T cells and protective effect on depigmentation. CD8<jats:sup>+<\/jats:sup> T cells were treated with antroquinonol <jats:italic>in vitro<\/jats:italic>, and C57BL\/6 mice were treated with antroquinonol with or without H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> <jats:italic>in vivo<\/jats:italic> for 50 consecutive days. We found antroquinonol could inhibit proliferation of CD8<jats:sup>+<\/jats:sup> T cells and suppress the production of cytokines IL\u20102 and IFN\u2010<jats:italic>\u03b3<\/jats:italic> and T cell activation markers CD69 and CD137 <jats:italic>in vitro<\/jats:italic>. H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> treatment induced depigmentation and reduced hair follicle length, skin thickness, and tyrosinase expression <jats:italic>in vivo<\/jats:italic>. Whereas, antroquinonol obviously ameliorated depigmentation of mice skin and resisted the reduction of hair follicle length, skin thickness, and tyrosinase expression induced by H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>. Antroquinonol decreased CD8<jats:sup>+<\/jats:sup> T cell infiltration in mice skin, inhibited the production of IL\u20102 and IFN\u2010<jats:italic>\u03b3<\/jats:italic>, and decreased the expression of CXCL10 and CXCR3. Summarily, our data shows antroquinonol inhibits CD8<jats:sup>+<\/jats:sup> T cell proliferation <jats:italic>in vitro<\/jats:italic>. It also reduces CD8<jats:sup>+<\/jats:sup> T cell infiltration and proinflammatory cytokine secretion and suppresses the thinning of epidermal layer <jats:italic>in vivo<\/jats:italic>. Our findings suggest that antroquinonol exerts immunosuppressive effects on CD8<jats:sup>+<\/jats:sup> T cell proliferation and activation to resist depigmentation induced by H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>.<\/jats:p>","DOI":"10.1155\/2017\/9303054","type":"journal-article","created":{"date-parts":[[2017,12,31]],"date-time":"2017-12-31T23:34:05Z","timestamp":1514763245000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Antroquinonol Exerts Immunosuppressive Effect on CD8<sup>+<\/sup> T Cell Proliferation and Activation to Resist Depigmentation Induced by H<sub>2<\/sub>O<sub>2<\/sub>"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9084-5418","authenticated-orcid":false,"given":"Cuiping","family":"Guan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingtian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuzu","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liuyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7255-086X","authenticated-orcid":false,"given":"Aie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,31]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12476645"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12103"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jidsp.5640189"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00697.x"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.3126\/kumj.v12i2.13660"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15681"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01459.x"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.LAB.0000069521.42488.1B"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037513"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12105"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.32"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2013.10.010"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.10.013"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007811"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.463"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(02)01686-7"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf0209701"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-818941"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.05.066"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-990232"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf4056924"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2015.01.012"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2009.08.022"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nen057"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.33328"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20090603"},{"key":"e_1_2_8_27_2","first-page":"1741","article-title":"Study on action of caltrop complex on vitiligo bearing mice and the mechanisms","volume":"35","author":"Gu H. 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