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We proposed to entrap MSCs within spherical particles derived from alginate, as a control, or from silanized hydroxypropyl methylcellulose (Si-HPMC). We developed water in an oil dispersion method to produce small Si-HPMC particles with an average size of about 68\u2009<jats:italic>\u03bc<\/jats:italic>m. We evidenced a faster diffusion of fluorescein isothiocyanate-dextran in Si-HPMC particles than in alginate ones. Human adipose-derived MSCs (hASC) were encapsulated either in alginate or in Si-HPMC, and the cellularized particles were cultured for up to 1 month. Both alginate and Si-HPMC particles supported cell survival, and the average number of encapsulated hASC per alginate and Si-HPMC particle (7102 and 5100, resp.) did not significantly change. The stimulation of encapsulated hASC with proinflammatory cytokines resulted in the production of IDO, PGE<jats:sub>2<\/jats:sub>, and HGF whose concentration was always higher when cells were encapsulated in Si-HPMC particles than in alginate ones. We have demonstrated that Si-HPMC and alginate particles support hASC viability and the maintenance of their ability to secrete therapeutic factors.<\/jats:p>","DOI":"10.1155\/2017\/9303598","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T19:31:01Z","timestamp":1507750261000},"page":"1-11","source":"Crossref","is-referenced-by-count":27,"title":["Polysaccharide Hydrogels Support the Long-Term Viability of Encapsulated Human Mesenchymal Stem Cells and Their Ability to Secrete Immunomodulatory Factors"],"prefix":"10.1155","volume":"2017","author":[{"given":"Fahd","family":"Hached","sequence":"first","affiliation":[{"name":"INSERM, UMR 1229, Regenerative Medicine and Skeleton (RMeS), Universit\u00e9 de Nantes, ONIRIS, 44042 Nantes, France"},{"name":"UFR Sciences Biologiques et Pharmaceutiques, Universit\u00e9 de Nantes, 44035 Nantes, 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