{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T07:14:50Z","timestamp":1770448490646,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011692","name":"General Insurance Association of Japan","doi-asserted-by":"crossref","award":["JP16H06280"],"award-info":[{"award-number":["JP16H06280"]}],"id":[{"id":"10.13039\/501100011692","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16H06280"],"award-info":[{"award-number":["JP16H06280"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>We investigated the clinical predictors of the degree of recovery in patients with prolonged disorders of consciousness (PDC) caused by traumatic brain injury. Fourteen patients with PDC underwent two diffusion tensor imaging (DTI) studies; the first and second scans were performed at <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn fontstyle=\"italic\">345.6<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">192.6<\/mml:mn><\/mml:math> and <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mn fontstyle=\"italic\">689.1<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">272.2<\/mml:mn><\/mml:math> days after the injury, respectively. In addition to the temporal changes in each of these diffusion parameters, fractional anisotropy (FA), mean diffusivity, axial diffusivity (AD), and radial diffusivity were assessed over a 1-year period. Relationship of clinical and DTI parameters with recovery from PDC (RPDC) was evaluated using Spearman\u2019s rank-correlation and stepwise multiple linear regression analysis. The mean FA and number of voxels with FA values &gt; 0.4 (VsFA0.4) were significantly decreased at the second scan. A significant positive correlation was observed between the degree of RPDC and mean FA (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.60<\/mml:mn><\/mml:math>) and VsFA0.4 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.68<\/mml:mn><\/mml:math>) as well as between the difference in VsFA0.4 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.63<\/mml:mn><\/mml:math>) and AD (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.54<\/mml:mn><\/mml:math>) between the first and second scans. On multiple linear regression analysis, initial severity of PDC and the difference in AD remained significantly associated with the degree of RPDC. The microstructural white matter changes observed in this study indicate their potential relation with the degree of RPDC over the longer term.<\/jats:p>","DOI":"10.1155\/2017\/9358092","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T23:35:19Z","timestamp":1487892919000},"page":"1-11","source":"Crossref","is-referenced-by-count":5,"title":["Predictors of Recovery from Traumatic Brain Injury-Induced Prolonged Consciousness Disorder"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3632-3165","authenticated-orcid":true,"given":"Hiroaki","family":"Abe","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Kohnan Hospital, Tohoku Ryogo Center, Sendai, Japan"},{"name":"Department of Physical Medicine and Rehabilitation, Graduate School of Medicine, Tohoku University, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keigo","family":"Shimoji","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihide","family":"Nagamine","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kohnan Hospital, Tohoku Ryogo Center, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kohnan Hospital, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-Ichi","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Graduate School of Medicine, Tohoku University, Sendai, Japan"},{"name":"Graduate School of Biomedical Engineering, Tohoku University, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2010.1429"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199411000-00002"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.52.11.804"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.08.035"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2013.3216"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-012-9174-3"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1017\/s1355617712000835"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm294"},{"issue":"5","key":"9","first-page":"794","volume":"23","year":"2002","journal-title":"American Journal of Neuroradiology"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2008.0839"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2008.0461"},{"issue":"12","key":"12","first-page":"1139","volume":"49","year":"1997","journal-title":"Brain and Nerve"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.10062"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm216"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1076"},{"issue":"3","key":"16","first-page":"370","volume":"25","year":"2004","journal-title":"AJNR American Journal of Neuroradiology"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.07.005"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1267"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20742"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2014.3750"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1053\/apmr.2001.25137"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.3109\/02699052.2011.558038"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31822c61d7"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.5.619"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2008.08.211"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20817"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3395"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2012.00160"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1097\/htr.0b013e318289ede5"}],"updated-by":[{"DOI":"10.1155\/2020\/7169025","type":"corrigendum","label":"Corrigendum","source":"publisher","updated":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T00:00:00Z","timestamp":1604880000000}}],"container-title":["Neural Plasticity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/2017\/9358092.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/2017\/9358092.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/2017\/9358092.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T16:33:09Z","timestamp":1589733189000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/np\/2017\/9358092\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":29,"alternative-id":["9358092","9358092"],"URL":"https:\/\/doi.org\/10.1155\/2017\/9358092","relation":{"corrigendum":[{"id-type":"doi","id":"10.1155\/2020\/7169025","asserted-by":"object"}]},"ISSN":["2090-5904","1687-5443"],"issn-type":[{"value":"2090-5904","type":"print"},{"value":"1687-5443","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}