{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T19:06:50Z","timestamp":1781032010198,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Objective.<\/jats:italic> To evaluate the efficacy and safety of the Xen Gel Stent and provide a macro- and microscopic analyses of bleb morphology. <jats:italic>Methods<\/jats:italic>. A prospective 12-month study on patients with primary open-angle glaucoma. Patients underwent implantation of the XEN Gel Stent (Allergan INC, Dublin, Ireland) either alone or combined with a cataract surgery. Biomicroscopy, in vivo confocal microscopy (IVCM), and anterior segment-optical coherence tomography (AS-OCT) were used to assess bleb morphology. Safety parameters were adverse events, best corrected visual acuity, visual field, and corneal endothelial cell loss. A postoperative IOP\u2009\u2264\u200918\u2009mmHg without or on medications was respectively defined as complete and qualified success while an IOP\u2009\u2265\u200918\u2009mmHg was defined as failure. <jats:italic>Results<\/jats:italic>. Twelve eyes of 11 patients were evaluated. At one year, 5 out of 10 patients available achieved a complete success while five were qualified success. AS-OCT showed that bleb wall reflectivity was significantly higher in the failure group; IVCM revealed that stromal density was significantly lower in the success group. No safety issues were recorded. <jats:italic>Conclusion<\/jats:italic>. Implantation of the XEN Gel Stent appears to be a safe and effective procedure. AS-OCT and IVCM may be helpful in bleb assessment.<\/jats:p>","DOI":"10.1155\/2017\/9364910","type":"journal-article","created":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T17:02:30Z","timestamp":1497978150000},"page":"1-9","source":"Crossref","is-referenced-by-count":44,"title":["Evaluation of Bleb Morphology and Reduction in IOP and Glaucoma Medication following Implantation of a Novel Gel Stent"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6551-6054","authenticated-orcid":true,"given":"Antonio Maria","family":"Fea","sequence":"first","affiliation":[{"name":"Clinica Oculistica, Dipartimento di Scienze Chirugiche, Universita' di Torino, Via Juvarra 19, 10100 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Spinetta","sequence":"additional","affiliation":[{"name":"Clinica Oculistica, Dipartimento di Scienze Chirugiche, Universita' di Torino, Via Juvarra 19, 10100 Torino, 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